Synthesis of 7-Substituted Fluoroquinolone Derivatives Contain- ing Triazolidine Dione Moiety and In Vitro Evaluation of Their Cytotoxic Effects
Journal Title: Journal of Reports in Pharmaceutical Sciences - Year 2013, Vol 2, Issue 1
Abstract
A series of fluoroquinolone derivatives holding triazolidindione moieties have been synthesized and proved to be cytotoxic agents in vitro particularly against cancer cell lines (SKNMC, MCF7, A2780-CP, SW48, A549, KB, HT-29, HepG2). The cytotoxic activity was assessed using MTT colorimetric assay. Our compounds had less cytotoxicity than doxorubicin in all studied cell lines.
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