SYNTHESIS OF NEW 1, 3, 7, 8-TETRASUBSTITUTED XANTHENES ANALOGUE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
Theophylline, a methyl xanthenes compound, is known as an efficient bronchodilator drug, having also anti-inflammatory and immunomodulatory effects. In order to improve its pharmacological profile and to reduce also the serious side effects that appear at high concentrations, new 1, 3, 7, 8-tetrasubstituted theophylline derivatives have been synthesized. The new compounds are obtained in two steps by the reaction of 8-substituted theophyllines with epoxy propyl acetaminophen. The chemical structure of the synthesized compounds has been elucidated by their 1H-NMR spectra. The potential bronchodilator effects of the synthesized compounds have been also established.
Authors and Affiliations
Abdulrahman Loay , Al-mousilly Maiada , Al-Halaibeh Tagreed , Al-Azzawii Khalid
Keywords
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