Synthesis of Possible Anti-Cancer and Anti-Mycobacterial Fluoro Substituted Sulphonamide Benzothiazoles Comprising Potent Thiazolidinone
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 3
Abstract
Abstract: In the present study, a series of N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[2-(3-nitrophenyl)-4-oxo-thiazolidin-3-yl]benzenesulphonamide and N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[2-(4-nitrophenyl)-4-oxo-thiazolidin-3-yl]benzenesulphonamide derivatives were synthesized in good yields and characterized by FTIR, 1HNMR, mass spectral and elemental analyses. All synthesized compounds were evaluated for their preliminary in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37 Rv strain by tube dilution assay method. Some selected synthesized compounds were also evaluated for cytostatic activities against malignant human cell lines: cervical (HeLa), bone marrow (K-562) and kidney cell (HEK-293). Keywords: Fluorobenzothiazole, Sulphonamido, Thiazolidinone, Anti-mycobacterial activity, Anti-cancer activity
Authors and Affiliations
Jagtap VA, Gautam DT, Mule VS, Gandhi SM, Jayachandran E
Keywords
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