Systemic Inflammation and Nitric Oxide Levels in the Patients with Type 2 Diabetes Mellitus
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 12
Abstract
Abstract: Presence of systemic inflammation is a hallmark of variety of pathophysiological such as hypertension, atherosclerosis, myocardial infarction and inflammatory joint diseases. Although previous evidences provided extensive literature about the low grade inflammation in Type 2 diabetes mellitus (T2DM), there is a paucity of satisfactory explanation regarding the alteration in the level of nitric oxide along with marker of systemic inflammation and lipid peroxidation in Type 2 DM patients. Therefore, the objective of present study was to estimate the level of C-reactive protein (CRP), malondialdehyde (MDA) and nitric oxide (NO) in T2DM patients and to determine its relation with future risk of atherosclerosis. 40 patients of either sex (35-50 years age group) suffering from T2DM and 40 normal healthy individuals served as control; were included in the study. Above mentioned parameters were estimated using standard methods and data from patients and controls were compared by using Student’s t-test and Pearson co-relation coefficient. In addition to hyperglycemia, erythrocyte MDA and plasma CRP levels were significantly high in T2DM subjects (P<0.001 & P<0.05) whereas plasma NO level was found to be significantly low (P<0.001) as compared to healthy controls and negative correlated with MDA and CRP levels (p<0.05). These findings suggest that collective effect of inflammation and oxidative stress on endothelial dysfunction plays a crucial role in the development of future atherosclerosis in T2DM, characterized by low nitric oxide levels and enhanced CRP and MDA levels. Thus, these markers should be monitored regularly in T2DM patients for early detection and adoption of preventive strategy against cardiac complications. Keywords:Oxidative stress, endothelial dysfunction, lipid peroxidation, C-reactive protein.
Authors and Affiliations
Sampath Kumar Velpula, Rentapalli Baburao
Keywords
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