T-cell-Mediated Immune Response in Women with Recurrent Miscarriage
Journal Title: International Journal of Science and Innovative Research - Year 2021, Vol 2, Issue 03
Abstract
Recent findings on the mechanisms of the molecules and cells underlying recurrent miscarriage have shown that immune cells play an important role in the semi-allogeneic of the embryo. Moreover, the tolerance of the maternal immune system is clearly determined by the types of immune cells. Experimental data have shown that the suppressive function of regulatory T cells (Tregs), through the production of IL-10 and TGF-beta, appears to protect against embryo implantation rejection. On the other side, T-helper (Th 1) cells act against trophoblast development by activating of decidual macrophage and conduct apoptosis of trophoblast cells, all of which is detrimental to pregnancy. Therefore, the paradoxical roles of the different types of immune cells during implantation and conception are investigated.
Authors and Affiliations
Asma Ahmed Alkailani, Khairiya Ohaida Ahmed
Keywords
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