Tachyphylaxis Demonstrated In The Effect Of Capsicum Annum On Gastric Acid Secretion.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Capsicum annum is one of the species of peppers that are used as culinary spices. The effect of edible substances on gastric acid secretion has been of interest but not much has been studied on Capsicums (peppers). This prompted the present study. Wistar rats weighing between 200-300 g were randomly placed in five groups having 8 rats per group and received aqueous extract of Capsicum annum. Doses of 10%, 20%, and 30% of LD50 and supramaximal doses of 10mg, 20mg, 30mg, 40mg, 50mg, 60mg, 70mg and 80mg of the aqueous extract were administered through a gastric fistula and 10 minutes aliquot samples collected over 120 minutes. Gastric acid secretion was measured by titrating the aliquots to phenolphthalein end point. The result of gastric acid secretion in mmol/L/hour was, basal acid output (BAO) 15.6 ± 0.19. 10% LD50 were 17.52 ± 0.03, 18.30 ± 0.03, 18.84 ±0.04, 19.20 ± 0.05, 19.08 ±0.07, 17.58 ± 0.16, 13.14 ± 0.24, 8.4 ± 0.16, 7.02 ± 0.13 at 40, 50, 60, 70, 80, 90, 100, 110, 120 minutes respectively. Results showed a rise between 50 and 90 minutes followed by decline between 90 and 120 minutes. This decline indicates that Capsicum annum demonstrates tachyphylaxis.
Authors and Affiliations
Dr. Nndunno Akwaras, Christian Onahinon, Dr. Emmanuel Eru, Dr Julie Ibu, Dr Adugba Augustine, Prof. John Ibu
Keywords
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