TECHNOLOGY OF PREPARATION AND EVALUATION OF KETOPROFEN-CHITOSAN SOLID DISPERSION
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2014, Vol 0, Issue
Abstract
The aim of the study was to investigate the effect of chitosan on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in physical mixtures at the drug to polymer ratios of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; the mean amount of dissolved ketoprofen and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multifold increase (33 times) in ketoprofen solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of ketoprofen in the presence of chitosan at the weight ratio 1:9 increased with the decrease of the molecular weight of the chitosan. The results obtained may help to develop new technologies for ketoprofen preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
Authors and Affiliations
Bożena Grimling, Maria Szcześniak, Jan Meler, Janusz Pluta
Keywords
Related Articles
- EP ID EP73397
- DOI 10.15259/PCACD.19.02
- Views 68
- Downloads 0
THERMAL DEGRADATION OF DOUBLE CROSSLINKED HYDROGEL CHITOSAN MEMBRANES
The thermal degradation behaviour of uncrosslinked and crosslinked chitosan membranes were studied by means of dynamic thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) over the temperature ran...
INFLUENCE OF A CHOSEN AUXILIARY SUBSTANCE ON THE PROPERTIES OF HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEX WITH CHITOSAN
The wide range of pH and viscosity of the investigated preparations shall enable selection of a gel with optimum pH and rheological properties. The value of pH of a gel have swollen is greatly influenced by the content o...
CYTOTOXICITY OF CHITOSAN BASED THERMO-SENSITIVE HYDROGELS INTENDED FOR NERVOUS TISSUE ENGINEERING
The damage to the central nervous system is one of the most difficult cases of trauma to treat. Over the last few years, increasing attention has been focused on the development of strategies based on biomaterials for re...
WETTING PROPERTIES OF CHITOSAN-MODIFIED AND PLASMA-TREATED PEEK SURFACES
In this paper, the wettability of chitosan/phospholipid (1,2-dipalmitoyl-sn-glycero-3-phosphocholine – DPPC), chitosan/lipid (cholesterol – Chol) and chitosan/protein (cyclosporine A – CsA) films on air plasma activated...
RESEARCH OF THE INFLUENCE OF CHITIN-CONTAINING FOOD ADDITIVES ON THE RHEOLOGICAL PROPERTIES AND BIOLOGICAL VALUE OF MINCED FISH
The problem of the deficiency of dietary fibre and mineral substances in the diet of modern man is well known. This problem is proposed to be solved by making a food product - fishballs - based on a combination of minced...