Teratogenic Effect of Lamotrigine on Developing Liver of Swiss Albino Mice
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
The aim of present study was to observe the noxious effect of Lamotrigine (LTG) in growing liver of mice .The pregnant mice (20-25 g) were treated orally with LTG during organogenesis period i.e. 7th - 9th day of gestation. The treated group received 0.3 ml (60 mg/kg body wt) of stock solution of LTG, whereas the same volume of distilled water was given to control mice via same route. The foetuses of both control and treated group were collected on 18th day of gestation and kept in 10 % formalin for fixation. After 48 hours of fixation, liver were taken out from foetuses and observed for gross anomaly, if any and then photographed. Finally, liver of both groups were processed for histological study. On macroscopic examination, the treated liver showed increase in weight and haemorrhagic spots especially on their lateral and inferior surfaces. On microscopic examination the treated group of liver showed loss of normal architecture of hepatic cords, oedematous spaces in hepatic lobules, dilated sinusoids and central vein with destruction of their lining endothelium. The present study revealed that the lamotrigine causes noxious effect on growing liver, therefore its use in pregnant women may be advised by experts working in the field.
Authors and Affiliations
Sharda Singh, S. K. Pandey, K. N. Dwivedi, Shweta Singh
Keywords
Related Articles
- EP ID EP588764
- DOI 10.9790/0853-16010298101
- Views 58
- Downloads 0
Surgical Management of a Periapical Cyst with an Alloplastic Bone Graft: A Case Report
It has been observed that the root canal treatment for the preservation of tooth having periapical pathology has shown over 90% of success whereas in the case where the canal is calcified, perforated, ledge is formed, an...
A Case Report of Partial Atrio Ventricular Canal on A 28 Years old Patient
Background: Partial AV canal defect is a form of endocardial cushion defect infrequently encountered in Adults. It includes an ostium primum atrial septal defect but with two separate atrioventricular valve rings and a c...
Adherance of Life Style Modification in Post Myocardial Infarction Patients
Abstract: Although preventive drug therapy is a priority after acute coronary syndrome, less is known about adherence to behavioral recommendations.According to the World Health Organization (WHO), 80% of premature heart...
An Unusual side effect of Clomiphene Citrate (Clomid)
Clomiphene citrate(Clomid) is a Selective Estrogen Modulator used to induce ovulation.1Many side effects of Clomiphene citrate were reported including mood swings and hot flashes.2 Stimulation of multiple follicles and c...
Bi – Atrial Myxoma Presenting As Acute Lower Limb Ischaemia in a Middle Aged Female: A Case Report
Atrial myxoma is a benign tumour of the heart and forms a very small percentage of all cardiac cases. When present, they are usually located within the left atrium and sometime in the right atrium on the interatrial sept...