Testosterone propionate stimulates leuco- and thrombocytopoiesis in rat model of androgen deficiency
Journal Title: PARIPEX-Indian Journal of Research - Year 2015, Vol 4, Issue 4
Abstract
There is scarce data about the influence of testosterone propionate on leucopoiesis in acute and chronic treatment, as in humans, thus experimentally. There is clinical and molecular-biological data that the sex hormones, and especially androgens influence the number and the functions of the thrombocytes. The aim of this study is to measure the dynamics in the values of serum testosterone and the number of the leucocytes and platelets during replacement therapy with testosterone propionate in dose 4 and 8 mg/kg body weight. (b.w.) in rat model of androgen deficiency. Conclusions: 1. 8 mg/kg b.w. of testosterone propionate, applied in rat model of androgen deficiency restores the physiological T levels. 2. Leucocyte stimulation was observed in 15 days testosterone propionate treated rats with androgen deficiency. 3. Transient platelet stimulation was observed after testosterone propionate administration in rats with androgen deficiency.
Authors and Affiliations
Delian Delev, Ilia Kostadinov
Keywords
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