The Ability of Hydroalcoholic Extract from UrticaDioica to Suppress Di-(2-Ethylhexyl) Phthalate’s Deleterious Effect on Glycemic Response in Mice
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 6
Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer to impart flexibility during the production of polyvinyl chloride (PVC) to make medical devices, food containers, etc. Ingestion of DEHP can raise obesity and type 2 diabetes epidemics. Urticadioica (UD) has been known as a plant that decreases blood glucose. The objective of this study was to determine the effect of hydroalcoholic extract from urticadioica on glycemic response against DEHP. An interventional study with 15 adult male mice was designed. Mice were randomly assigned to 3 equal groups: control, DEHP (dose of 250 mg/kg/day), DEHP (dose of 250 mg/kg/day) plus extract of UD (dose of 100 mg/kg/day). They were treated for a period of 8 weeks. The formulated diet was common chow plus tallow (1:1). At the end, fasting blood samples were used to measure the variables. Serum glucose and insulin resistance (IR) levels of group 2 (DEHP 250 mg/kg) and group 3 (DEHP 250 mg/kg with extract of UD100 mg/kg/day) compared to the control group were increased significantly and also the insulin resistance (IR) level of group 3 compared to group 2 was decreased significantly (P < 0.05). The quantitative insulin sensitivity check index (QUICKI) levels of group 2 and group 3 compared to the control group were decreased significantly (P < 0.05). There were no significant changes in levels of serum insulin, glycated hemoglobin (HbA1c) of total blood and area under the curve in glucose tolerance test (AUC) (P > 0.05). In this study, it was shown that DEHP (250 mg/kg) impaired blood sugar control systems which can lead to prediabetes. We suggest that the extract of UD, by decreasing the IR level, may be useful to improve blood sugar control systems and may not be useful for reducing serum glucose level against DEHP.
Authors and Affiliations
BehzadNajmi Kargan, SanazAnvari Azar, Maryam Mahmoodi Momenabadi, Ranim Shartouni, Reza Fathi
Keywords
Related Articles
- EP ID EP406466
- DOI -
- Views 113
- Downloads 0
Cornea plana: a case report
We report a case of a 7-yeas old boy with Cornea plana who presented with heavy amblyiopia due to high refractive error. Cornea plana is a genetically determined condition that can be accompanied by a range of complicati...
Role of Adjuvant Therapy in Osteoradionecrosis (Orn) and Bisphosphonate Induced Osteonecrosis of Jaw (Bronj)
Aim; A treatment procol with pentoxifylline(PT) and A- tocoferol combination therapy to assess the utility along with standard antimicrobial therapy in a series of cases of ORN (osteoradionecrosis) of jaw and BRONJ. Mate...
Dissolution Enhancement of BCS Class 4 Dssrugs Using Quality by Design Approach with Solid Dispersion Technique
Solid dispersion is one of the vastly accepted and practically economical processes in bioavailability enhancement study. The present investigation deals mostly with increase in solubility and dissolution rate of BCS cla...
A Study on The Applications of Silver Nanoparticle Synthesized Using The Aqueous Extract And The Purified Secondary Metabolites of Lichen Parmelia perlata
Lichens are generally a symbiotic association between a fungal and an algal partner. They produce an array of secondary metabolites that are common in plants or higher fungi but 80% of metabolites are produced specifical...
A Variety of Anatomical and Clinical Manifestations of Myelinated Retinal Nerve Fibers
Introduction: Myelinated Retinal Nerve Fibers (MRNF) represent a developmental anomaly that occurs in about 1% of the population. They appear as different in size, well demarcated white striated lesions along the retinal...