The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Introduction: Beta-galactosidase (GAL) is a lysosomal exoglycosidase involved in the catabolism of glycoconjugates through the sequential release of beta-linked terminal galactosyl residues. The stimulation of activity of exoglycosidases and other degradative enzymes has been noted in cancers as well as in alcohol and nicotine addiction separately. This is the first study to evaluate the activity of the serum senescence marker GAL in colon cancer patients with a history of alcohol and nicotine dependence, as a potential factor of worse cancer prognosis.Material and Methods: The material was serum of 18 colon cancer patients and 10 healthy volunteers. Ten colon cancer patients met alcohol and nicotine dependence criteria. The activity of beta-galactosidase (pkat/ml) was determined by the colorimetric method. Comparisons between groups were made using the Kruskal-Wallis analysis and differences evaluated using the Mann-Whitney U test. Spearman’s rank correlation coefficient was used to measure the statistical dependence between two variables.Results: The activity of serum GAL was significantly higher in colon cancer patients with a history of alcohol and nicotine dependence, in comparison to colon cancer patients without a history of drinking/smoking (p=0.015; 46% increase), and the controls (p=0.0002; 81% increase). The activity of serum GAL in colon cancer patients without a history of alcohol/nicotine dependence was higher than the activity in the controls (p = 0.043; 24% increase).Discussion/Conclusion: Higher activity of beta-galactosidase may potentially reflect the accelerated growth of the cancer, invasion, metastases, and maturation, when alcohol and nicotine dependence coincide with colon cancer. For a better prognosis of colon cancer, alcohol and nicotine withdrawal seems to be required.
Authors and Affiliations
Napoleon Waszkiewicz, Sławomir Dariusz Szajda, Magdalena Waszkiewicz, Aleksandra Wojtulewska-Supron, Agata Szulc, Alina Kępka, Sylwia Chojnowska, Jacek Dadan, Jerzy Robert Ładny, Krzysztof Zwierz, Beata Zalewska-Szajda
Keywords
Related Articles
- EP ID EP67030
- DOI -
- Views 121
- Downloads 0
Metformin – mechanisms of action and use for the treatment of type 2 diabetes mellitus
Metformin is widely used for the treatment of type 2 diabetes mellitus. Although this biguanide derivative has been used for more than 50 years, its mechanism of action has not been fully elucidated. In this article we...
Szałwia hiszpańska (chia) jako bogate źródło kwasów wielonienasyconych n-3 o działaniu przeciwmiażdżycowym i kardioprotekcyjnym
Chia (Salvia hispanica L.) to jednoroczna roślina z rodziny jasnotowatych (Lamiaceae), pochodząca z terenów Mezoameryki – głównie z obszaru obejmującego dzisiejszy Meksyk i Gwatemalę, gdzie jest uprawiana od kilku tysięc...
Heparin-free hemodialysis
Hemodialysis is the most widely applied renal replacement therapy. Due to the fact that the hemocyte - dialyzer contact leads to the activation of the coagulation pathway, adequate anticoagulation to provide fluent blood...
Comparison of Haptoglobin and Alpha1-Acid Glycoprotein Glycosylation in the Sera of Small Cell and Non-Small Cell Lung Cancer Patients
Introduction: Cancer-related carbohydrate epitopes, which are regarded as potential diagnostic and prognostic biomarkers, are carried on the main acute phase proteins. It is not clear, however, if the glycosylation profi...
Amylina w badaniach eksperymentalnych. Fibrylotwórczy polipeptyd amyloidu trzustkowego
W przebiegu cukrzycy typu 2 (diabetes mellitus type 2 DM2, non-insulin dependent diabetes mellitus, NIDDM) oraz w rozwoju guza insulinowego trzustki, obserwuje się w obrębie wysp Langerhansa patologiczne depozyty zwane a...