The Ambiguous Role of Hemostatic Matrix in Total Knee Arthroplasty: A Randomized Controlled Trial
Journal Title: Kerala Journal of Orthopaedics - Year 2018, Vol 0, Issue 0
Abstract
Background: Blood loss which is one of the major complications following major surgeries and leads to significant morbidity and substantially increases the need for blood transfusions. Use of hemostatic agent’s intraoperatively is one of the widely used techniques to reduce blood loss. The use of hemostatic agents to reduce blood loss has been widely studied with mixed results. The aim of this study was to evaluate whether the use of Floseal®, a hemostatic most commonly used in our hospital as an adjuvant to conventional hemostasis reduces blood loss and reduces the requirement of transfusions postoperatively in patients undergoing total knee arthroplasty (TKA). Materials and Methods: This study was a prospective randomized controlled trial conducted on 67 female patients operated between January 2012 and January 2013 with the primary endpoint being blood loss as estimated by a decrease in hemoglobin (Hb) on days 0, 1, and 4 postoperatively. The number of transfusions required postoperatively was also assessed. The patients were divided into two groups: Group A and Group B. Group A consisted of 35 patients in whom the hemostatic was not used. Group B consisted of 32 patients in whom 5ml of hemostatic matrix Floseal®. All the statistical analyses were performed using GraphPad Prism 7.0. Results: Sixty-seven patients participated in the study, and the data of all the patients were analyzed. The demographic data and the mean percentage decrease of Hb from pre-operative values were analyzed which did not show any statistical difference. The odds ratio and relative risk were less than one and were not statistically significant. Conclusion: The use of a hemostatic agent does not necessarily decrease the need for blood transfusions postoperatively, and the role of hemostatic agents in TKA for reducing blood loss remains uncertain.
Authors and Affiliations
Appu Benny Thomas, Jacob Varghese, Gnanavel Gnanavel, J C Vinay J C Vinay, Biju Pankappilly
Keywords
Related Articles
- EP ID EP571478
- DOI -
- Views 92
- Downloads 0
A Comparison between Volar Plating and K-wire Fixation of Distal End Radius Fractures
Introduction: Distal end radius fracture is a common fracture seen in the routine orthopaedic practice. The optimal management of distal radius fractures remains controversial [1]. The aim of this study is to prospective...
Fabella Syndrome – A Rare cause of Posterolateral Knee Pain: Case Report and Review of Literature
Introduction: The purpose of this article is to educate clinicians about fabella syndrome as a possible cause of posterolateral knee pain and dysfunction. We report a case of a teenager who presented with posterolateral...
Surgical Management of Spinal Metastasis – A Retrospective Analysis of 150 Cases
Introduction: PIntroduction: A Surgical management of spinal metastasis controversial in terms of average life expectancy of the patient [1]. No one can accurately determine the exact life expectancy of a patient. Mater...
Bilateral Innominate Osteotomy in the Management of Exstrophyepispadias Complex – A Case Report
Introduction:Bladder exstrophy is a developmental defect presenting with a wide pubic separation and an exposed bladder at birth resulting from abnormal anterior rupture of the cloacal membrane early in the embryonic per...
KOA Fellowship Report
I, Dr.Saju.S, Assistant Professor Orthopaedics currently working in Government medical college Kottayam was really excited when I was selected for KOA fellowship 2018. I was eager to upgrade my arthroscopy skills especia...