The Antihyperlipidemic Effects of Resveratrol in Rats with Simultaneous Type II Diabetes and Renovascular Hypertension
Journal Title: International Cardiovascular Research Journal - Year 2016, Vol 10, Issue 4
Abstract
Background: Resveratrol has beneficial effects on experimental and clinical hypertension and diabetes. Objectives: This study aimed at examining antidiuretic and antihyperlipidemic effects of resveratrol in rats with simultaneous type II diabetes and endovascular hypertension. Materials and Methods: This study was performed on eight groups of male Spargue- Dawley rats each containing 8 - 10 animals as follows: control, diabetic (induced by streptozotocin and nicotinamide), renovascular hypertensive (induced by placing Plexiglas clips on the left renal arteries), sham, simultaneously hypertensive–diabetic receiving vehicle (distilled water), and 3 simultaneously hypertensive-diabetic groups receiving 5, 10, and 20 mg/kg/day resveratrol. Blood pressure and heart rate were measured weekly and fasting blood glucose, serum cholesterol, triglyceride, and markers of oxidative stress were measured after 4 weeks of treatment with resveratrol vehicle. The data were analyzed using one-way Analysis of Variance (ANOVA) and Duncan’s multiple range tests. Data analysis was done using SigmaStat software and P ≤ 0.05 was considered to be statistically significant. Results: Serum malondialdehyde, systolic blood pressure, heart rate, fasting blood glucose, blood glycated hemoglobin, and serum triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels were significantly higher in the hypertensivediabetic group receiving vehicle compared to the control group (P < 0.05) and treatment with resveratrol significantly reduced these variables (P < 0.05). On the other hand, serum superoxide dismutase, glutathione reductase, and high-density lipoprotein cholesterol levels were significantly lower in the hypertensive-diabetic group receiving vehicle compared to the control group (P < 0.05) and treatment with resveratrol significantly increased these variables (P < 0.05). Conclusions: The findings indicated that resveratrol had antidiabetic, antihypertensive, and antihyperlipidemic effects, which might be partly due to an antioxidant mechanism.
Authors and Affiliations
Masoud Mozafari, Ali Akbar Nekooeian, Mohammad Reza Panjeshahin
Keywords
Related Articles
- EP ID EP395625
- DOI -
- Views 126
- Downloads 0
A Survey on Structural and Functional Cardiac Abnormalities in Transfusion-Dependent Thalassemia, a Report from South-East of Iran
Background: Cardiac abnormalities are common complications in Transfusion Dependent Thalassemia (TDT). Objectives: This study aimed to assess functional and structural cardiac abnormalities in TDT patients in Zabol, Sist...
The Association between Serum Resistin Level and Presence or Severity of Coronary Heart Disease
Background: Obesity is a well-known principal risk factor for metabolic disorders and cardiovascular diseases. Resistin is one of adipocyte-derived molecules, which plays important roles in inflammation as well as in end...
The Discovery of Major Heart Risk Factors among Young Patients with Ischemic Heart Disease Using K-Means Techniques
Background: Ischemic Heart Disease (IHD) is the leading cause of mortality in both developed and developing countries. It accounts for more than 15% of the total mortality worldwide. At the global scale, the massive occu...
The Effect of Fasting on Anthropometric Parameters and Blood Pressure Levels: A Report from Southern Iran
Background: Ramadan is the fasting month among Muslims and the change in eating and sleep pattern can cause changes in human health. Objectives: This study was carried out to determine the effect of fasting in Ramadan on...
Corrigendum to: The Association between PAI-1 Gene Promoter Polymorphism and Serum Serpin E1, MDA, and Hs-CRP Levels in Coronary Artery Disease [published in Int Cardiovasc Res J.2016;10(3):129-134.icrj.35403]
This corrigendum/addendum supplies corrected statements and proofs of an error by the authors. Hereby, the authors declare that the corrected authors’ list and affiliations are: Ansar Karimian 1, Safar Farajnia 2, Mortez...