The Association between Helicobacter Pylori Infection and Parkinson's Disease: A Case-Control Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
ABSTRACT Introduction: Conflicting results have been reported about the association between Helicobacter pylori infection and Parkinson's disease. Aim: To evaluate the relation between H. pylori infection and Parkinson's disease in patients living in northern Iran. Materials and Methods: In this case-control study, 99 consecutive patients with Parkinson's disease visiting a Neurology Clinic were included. Also, 297 controls were chosen from the participants of the Amirkola Health and Ageing Project, who were matched to the patients with Parkinson's disease for sex, age and educational level. H. pylori infection was assessed by IgG Enzyme-Linked Immunosorbent Assay. The severity of Parkinson's disease was assessed by using the Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn and Yahr Scale (HYS). Results: A rate of 66.7% (n=33) of the patients with Parkinson's disease were positive for H. pylori infection, while it was 79.5% (n=236) in the controls {Odds Ratio (OR)=0.52, 95% Confidence Interval (CI)=0.31-0.86, p=0.01}. Scores of UPDRS and HYS were less in H. pylori-positive Parkinson's disease patients than in those who were not infected, however, the differences were not significant. Conclusion: The results of this study suggest that H. pylori infection may protect people from Parkinson's disease. More definitive studies are necessary to confirm this finding.
Authors and Affiliations
Tahereh Babajani Roshan, Ali Bijani, Seyed Reza Hosseini, Mojgan Bagherzade, Payam Saadat, Mohammad Zamani
Keywords
Related Articles
- EP ID EP526643
- DOI 10.7860/JCDR/2018/37178.12088
- Views 83
- Downloads 0
Evaluation of Diagnostic Efficacy of Pipelle Endometrial Sampling in Abnormal Uterine Bleeding
ABSTRACT Introduction: Abnormal Uterine Bleeding (AUB) is a major clinical problem among women in peri and postmenopausal age groups which needs complete scrutiny. Various methods are in vogue for the assessment of endom...
Osteoporosis at Distal Radius in Otherwise Healthy Adult Patients with Type 2 Diabetes: Does it differ from Routine?
ABSTRACT Introduction: Type 2 Diabetes Mellitus (T2DM) affects bone metabolism at axial as well as the appendicular skeleton. Bone loss may vary at different sites. Besides spine and hip, the distal radius is commonly ev...
Contribution of Corollary Discharge in Elderly People with Peripheral Proprioception Deficit
ABSTRACT Introduction: Corollary discharge which is otherwise known as sense of effort is assumed to be the internal signal that arises from centrifugal motor command and that influences perception of movement. This prov...
An Interesting and Rare Case of Urachal Adenocarcinoma Enteric Type with Review of Literature
ABSTRACT The urachus is a tubular structure that connects the bladder and allantois in the embryonic development, which involutes after third trimester. Urachal tumours are extremely rare and accounts of about 0.3-0.7% o...
Management of an Electrocuted Burn Injury in a District Hospital-A Case Report and Literature Review
ABSTRACT Electrical burns are one of the important health burdens throughout the world with incidences varying between 4-18% of all burns. They comprise of several types, including lighting injury, high voltage injury (>...