The Association of Adiponectin Gene Polymorphisms (-11391G/A), (+45T/G) With WC and Type 2 Diabetes in North East India
Journal Title: International Journal for Research in Applied Science and Engineering Technology (IJRASET) - Year 2016, Vol 4, Issue 3
Abstract
Background: Adiponectin is a protein, secreted from adipose tissue, according to numerous studies that have been done before, its plasma levels are associated with different parameters of metabolic syndrome. It seems that this effect results from the interaction of genetic (polymorphisms in the adiponectin gene) and environmental factors (obesity). The present study aimed to investigated the possible association between two SNPs of adiponectin gene at position (+ 45T/G) and (-11391G/A) with increased of waist circumference (WC) and type 2 diabetes mellitus patients in North East, Guwahati, india. Method: This study is a case - control study with 121 diabetic patients were selected as cases group and 87 healthy people selected as controls group. After extraction of DNA, genotyping was performed by PCR-RFLP method. Results: We don’t observed a significant association between adiponectin gene polymorphism (+45T/G) and waist circumference (WC). In diabetic patients over 40 years old we observed a significant association between adiponectin gene polymorphism (- 11391 G/A) and waist circumference(WC) (P = 0.021). Conclusion: It seems that the role of adiponectin polymorphism (+45 T / G)in the creation of type 2 diabetes independent to abdominal obesity and adiponectin polymorphisms of ( -11391G / A) in type 2 diabetes depend to abdominal obesity in people older than 40 years (waist circumference <90).
Authors and Affiliations
Majid Khandouzi, Leila Haghshenas, Manab Deka, Morteza Kordafshari,
Keywords
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