The association of serum uric acid with total white blood cell count in a healthy Indian adult population
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 3
Abstract
Background: Atherosclerosis is the underlying cause for nearly all cases of Coronary Artery Disease (CAD) which is a major cause of mortality in men and women. Numerous studies state that the basic pathology behind atherosclerosis is inflammation and oxidative stress. Though uric acid is an anti oxidant, recently studies show that it can be transported across the cell membrane and exert harmful intracellular actions such as oxidation and inflammation. These observations led to many epidemiological studies suggesting that uric acid is linked to and may be a risk factor for CAD. The aim of this study was to evaluate whether there is an association between serum uric acid and total white blood cell count, a simple marker of inflammation, in a healthy Indian adult population. Method: This is a cross sectional study. Samples were collected for assaying serum uric acid, total white blood cell count and plasma glucose, along with the medical history from 203 apparently healthy individuals who attended health examination at Sri Ramachandra Medical Centre in Chennai. Result: The results obtained were subjected to statistical analysis in SPSS software version 16. There was a strong positive correlation between uric acid and total white cell count and the study revealed no significant difference in mean levels of uric acid in tobacco users and non-users. And there was no statistically significant difference between genders in the mean uric acid level. Conclusion: A strongly positive correlation was found between serum uric acid and total white cell count, both in men and women. It appears likely that additionally larger well designed prospective studies that adjust for all possible confounding factors may help to strongly establish the correlation between serum uric acid and total white cell count and their role in proinflammatory states as in atherosclerosis.
Authors and Affiliations
Sathya Selvarajan, Jothimalar R, Santhi Silambanan
Keywords
Related Articles
- EP ID EP242785
- DOI -
- Views 99
- Downloads 0
Biochemical markers for early detection of cardiovascular disease in smokers
Introduction: The prevalence of coronary heart disease (CHD) is increasing in urban as well as rural areas in India especially during the last decade due to adoption of smoking habits. Tobacco smoking is currently ranked...
Pitfalls of currently practiced approach for teaching medical students: opinions & options
Introduction: During a didactic lecture, information is given to the students by the teacher, where students are passive listeners and the teacher is the narrator. Interaction between the students and the teacher, though...
Effect of Cigarette Smoking on Serum Lipid Profile in Male Population of Udaipur (Rajasthan)
Cigarette Smoking is associated with adverse effects on lipid profile and Homocysteine thus increasing risk for atherosclerosis and coronary heart disease. Smoking is a prominent risk factor for coronary artery disease,...
A Study of Vitamin D Levels in Patients of Prostate Cancer
Background: Prostate cancer is the second most common cancer among men worldwide contributing to three fourth of the registered cases across the globe. Although it is more common in western countries, its incidence is ri...
Normative data of the urinary bone resorption biomarkers for osteoporosis DPD, CTx and NTx among females in Manipur and its correlation with bone mineral density measured by DEXA scan
Introduction Osteoporosis has become a major public health problem affecting more than 100 million people worldwide Standard diagnosis depends on measuring bone mineral density BMD using a dual energy Xray absorptiometry...