The Benefit of Montelukast in Atopic Dermatitis Induced by Food Allergies
Journal Title: Global Journal of Allergy - Year 2017, Vol 3, Issue 1
Abstract
Background: Cysteinyl leukotriene levels are elevated in patients with atopic dermatitis, which can lead to eosinophilic infiltration of the gastrointestinal tract. Objective: We examined the role that montelukast (a leukotriene receptor antagonist) might play in improving symptoms of atopic dermatitis induced by food allergies. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel group study in 20 children, aged 1 to 8 years, with 4 study visits every 3 weeks for 9 weeks. Primary inclusion criteria consisted of: 1) positive reactivity to food (indicated by skin or RAST test); 2) 10–25 % body area affected with atopic dermatitis; and 3) gastrointestinal symptoms. Liquid cetirizine and 1% hydrocortisone cream were both given as rescue medications for atopic dermatitis flare-ups. Pruritis and atopic dermatitis flare-up scores were used to collect clinical data. Laboratory values for nerve growth factor were evaluated pre- and post-treatment. Results: Our main endpoints were the effects of montelukast on the clinical presentation of atopic dermatitis. When comparing the treatment group to placebo, we noted a significant reduction in the pruritis score (p=0.002); a trend toward a reduction in the use of rescue medication (cetirizine: p=0.056; hydrocortisone cream: p=0.056); and a reduction in the level of nerve growth factor; mean values: placebo=3.06 to montelukast=2.59. Conclusion: The inflammatory pathway triggered by food allergies that may lead to atopic dermatitis can be modulated with montelukast. Furthermore, nerve growth factor may play a role in the pathogenesis of atopic dermatitis and montelukast may modify this pathway.
Authors and Affiliations
Melamed Isaac, Robinson Lacey, Heffron Melinda
Keywords
Related Articles
- EP ID EP342765
- DOI 10.17352/2455-8141.000018
- Views 93
- Downloads 0
Impact of Food Allergies on the Allergic Person’s Travel Decision, Trip Organization and Stay Abroad
This survey evaluated the impact of food allergy on the allergic person’s travel decision, trip organization and stay abroad. Hundred and two persons have participated. Results show that food allergy prevents 14% of resp...
ANTI-Ige: An Overview
Asthma is common chronic inflammatory disease of the airways characterised by variable and attacks of cough and breathlesness, usually precipitated by an enviromental trigger (air pollution, smoke, etc). The prevalence a...
Polyphenols and their Mechanism of Action in Allergic Immune Response
Mini review article deals with the most studied group of chemical compounds – polyphenols – predominantly flavonoids in relation to their allergic immune response. There is clarified and discussed their mechanism of acti...
Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma
The importance of diet and supplement intake in the onset and development of asthma has been advocated recently, and it may be important in the prevention and management of bronchial asthma. Long-chain n-3 polyunsaturate...
Iodixanol Nasal Solution Reduces Allergic Rhinoconjunctivitis Signs and Symptoms in Allergen BioCube®: Randomized Clinical Trial
Purpose: Allergic rhinitis (AR) affects ~20% of the population worldwide. The objectives of this study were to evaluate the safety and efficacy of iodixanol nasal solution (Nasapaque) for AR treatment, using the Allergen...