THE CAUSE OF THE RELATIONSHIP BETWEEN PROSTATE SPECIFIC ANTIGEN AND RENAL FUNCTION ASSOCIATED PARAMETERS: AGE
Journal Title: Kocatepe Medical Journal - Year 2023, Vol 24, Issue 2
Abstract
OBJECTIVE: It was aimed to investigate the relationships between creatinine, estimated glomerular filtration rate (eGFR), urea, uric acid and prostate specific antigen (PSA) levels, that are used in screening, diagnosis and follow-up of prostate and kidney diseases that are common in older man. MATERIAL AND METHODS: Simultaneously requested serum PSA, creatinine, urea and uric acid results of 7203 males above 40 years old between September 2017 and March 2020 were retrospectively analyzed. The correlations between parameters were evaluated with the effect of age. In addition, the bidirectional relationship between PSA elevation and eGFR decrease was also examined. RESULTS: There were no effect of creatinine, urea and uric acid levels on PSA levels (p=0.63, p=0.28 and p=0.39, respectively) and similarly, there were no effect of PSA levels on creatinine, urea and uric acid levels (p=0.22, p=0.25 and p=0.92, respectively) when adjusted for age. In the regression analysis with age; while the risk of PSA elevation increased 1.09 times as age increased, it was found that the risk did not show a significant change as creatinine increased (p<0.001 and p=0.99, respectively). Similarly, while the risk of moderate/severe eGFR decrease increased 1.11 times as age increased, it was found that the risk did not show a significant change as PSA increased (p<0.001 and p=0.31, respectively). CONCLUSIONS: In the light of the findings of the study, it is concluded that the risk of increased PSA and creatinine levels increases with advancing age. The relationship between PSA and creatinine levels disappears and they do not effect each other when age variable is taken into account.
Authors and Affiliations
Eren VURGUN
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- EP ID EP722639
- DOI https://doi.org/10.18229/kocatepetip.1076742
- Views 47
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