The Clinical Outcome among the Patients of Guillain Barre Syndrome After Therapeutic Plasma Exchange: Critical Reassessment of Effectiveness at BSMMU
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 5
Abstract
Introduction: Guillain–Barré syndrome (GBS) is an acute monophasic paralyzing illness usually provoked by a preceding infection. Mainly intravenous immunoglobulin (IVIG) and plasmapheresis (PP)/plasma exchange (PE) are used to treat this disease where for developing country IVIG is not cost effective and suitable. Objective: In this study our main goal is to evaluate the clinical Outcome among the Patients of Guillain Barre Syndrome after therapeutic plasma exchange. Method: This open label randomized clinical control trial was carried out at Department of Transfusion Medicine of BSMMU, Dhaka from April 2017-December 2017.The patients who are candidate for IVIg will be enrolled. One group received TPE and other will be treated in the conventional manner and conducted as control.40 patients with the age range of 15 to 60 years admitted to Intensive care unit of BSMMU and referred to neurology Department of this hospital for performing TPE. All patients had clinical findings of Guillain-Barre syndrome (GBS) and/or GBS variants. Results: During study it was observed that 4(20.0%) patients belonged to age 25-34 years, 35-44 years and 45-54 years respectively in TPE group and 35-44 years and 45-54 years respectively in IvIg group and direct costs of IVIg therapy are more than twice that of TPE. Also patient's condition started improving after three cycles of TPE with power in the upper limbs 4/5 and lower limbs 3/5. Conclusion: It can be concluded that TPE appears to be a less expensive and most effective first-line therapy option for treatment of patients with GBS.
Authors and Affiliations
Sheikh Anisul Haque, Fahmida Kabir, Sanjeela Nahreen Chowdhury, MdSaif Bin Mizan, Sumaya Afroze
Keywords
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- EP ID EP537034
- DOI 10.21276/ijmrp.2018.4.5.045
- Views 97
- Downloads 0
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