The Comparison of the Influence of Thiopental and Propofol on Intraocular Pressure during Induction of Anesthesia in Intubated Patients under Cataracct Surgery
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 7
Abstract
The prevention of the increase of intraocular pressure and the further decrease of it during eye surgery has an impressive effect on the success of surgery. Some of the phases of the induction of anesthesia like laryngoscopy and tracheal intubation result in the increase of intraocular pressure and its consequences are dangerous for penetrating injuries of eyeball. The goal of this research is the comparison of the changes of intraocular pressure during the induction of anesthesia in completely same conditions by using thiopental and propofol and also the careful investigation of their influences on intraocular pressure in order to select the medicine that effectively decrease the intraocular pressure and prevent the increase of it after laryngoscopy and tracheal intubation. In this research, 88 patients were selected and they were randomly divided into 2 groups. In the beginning of the patients' anesthesia, both groups were preoxygenated and they simultaneously receive initial dose of atracurium (0/5 mg/kg) and then initial dose of fentanyl (1-2 µg/Kg). After prescription of fentanyl, the induction of anesthesia in the first group was done withthiopental (4 mg/kg) and in the second group with propofol (2/5 mg/kg) and after that, atracurium intubation (0/7 mg/kg) was prescribed. Intraocular pressure is measured in two phases before induction of anesthesia (with tetracaine eyedrop) and 3 minutes after intubation (with schiotz tonometer and 3±0/75 degree of accuracy) and by a person who is not aware of the kind of anesthesia. The patients are replicated in 2 experimental and control groups in terms of age and gender. The results of independent t-test show that there is no significant difference between 2 groups of thiopental and propofol in terms of systolic and diastolic blood pressure, heart beat and eye pressure before the induction of anesthesia (p-value>0,05). The results of independent t-test show that there is a significant difference between2 groups of thiopental and propofol in terms of diastolic blood pressure and eye pressure after the induction of anesthesia (p-value<0,05). But there is no significant difference between 2 groups of thiopental and propofol in terms of systolic blood pressure and heart beat after the induction of anesthesia (pvalue>0,05). After the induction of anesthesia, the amount of systolic blood pressure and eye pressure was higher in thiopental than propofol. Propofol results in the decrease of intraocular pressure more than thiopental and it effectively prevents the increase of intraocular pressure after laryngoscopy and tracheal intubation.
Authors and Affiliations
Reza Sahraei| Medical Ethic Research Center, Jahrom University of Medical Sciences, Jahrom, Iran, Department of Anaesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran, Hossein Kargar Jahromi| Research center for Non.Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran Correspondence Email:hossein.kargarjahromy@yahoo.com, Mohsen Adelpour| Medical Ethic Research Center, Jahrom University of Medical Sciences, Jahrom, Iran, Department of Anaesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran, Navid Kalani| Medical Ethic Research Center, Jahrom University of Medical Sciences, Jahrom, Iran, Department of Anaesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran, Fatemeh Eftekhareian| Medical Ethic Research Center, Jahrom University of Medical Sciences, Jahrom, Iran, Department of Anaesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran
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