The Contribution of Serotonergic Receptors and Nitric Oxide Systems in the Analgesic Effect of Acetaminophen: An Overview of the Last Decade
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 1
Abstract
Acetaminophen is a widely used analgesic and antipyretic agent. It is also available in over the counter formulations, which has increased its wide use. There have been many studies to date that have aimed to evaluate the mechanism of the analgesic action of acetaminophen. Additional to the inhibition of the cyclooxygenase pathway in the central nervous system, the involvement of opioidergic, cannabinoidergic, dopaminergic, cholinergic, and nitrergic systems as well as the contribution of descending pain inhibitory systems like the bulbospinal serotonergic pathway has been proposed as possible mechanisms of the analgesic action of acetaminophen. In this review, we aimed to collect the data from studies revealing the contribution of the central serotonergic system and the role of central nervous system-located serotonergic receptor subtypes in the analgesic effect of acetaminophen. While doing this, we mainly focused on the research that has been performed in the last ten years and tried to link the previous data with the lately added results. In addition to serotonergic system involvement, we also reviewed the role of nitric oxide in the analgesic action of acetaminophen, especially with the new findings reported over the last decade.
Authors and Affiliations
Yeşim HAMURTEKİN, Ammar NOUILATI, Cansu DEMİRBATIR, Emre HAMURTEKİN
Keywords
Related Articles
- EP ID EP684739
- DOI 10.4274/tjps.galenos.2018.35403
- Views 182
- Downloads 0
Statistical Design and Optimization of Sustained Release Formulations of Pravastatin
Objectives: The objective of the current study was to formulate a sustained release (SR) formulation for pravastatin. Pravastatin is a lipid lowering, biopharmaceutical classification class-III agent. Materials and Meth...
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Mater...
Flavonoid Glycosides from Heracleum pastinaca Fenzl
Objectives: The objective was to isolate and characterize the secondary metabolites of Heracleum pastinaca, which has not been previously investigated. Materials and Methods: Conventional chromatographic procedures were...
A Controlled Release Theophylline Delivery System Based on a Bilayer Floating System
Objectives: Bilayer floating drug delivery is an approach that helps to overcome the shortcomings of single-layered tablets. There is little or no fluctuation of the drug in the blood stream or tissue, while control is e...
Cytotoxic and Antileishmanial Effects of Various Extracts of Capparis spinosa L.
Objectives: Cutaneous leishmania sis (CL) is considered as one of the most critical infections worldwide, in which the protozoa of the genus Leishmania infects a person. Today, the common and selective drugs for the trea...