The correlation between serum homocysteine levels and hypothyroidism: A 1-year case control study
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2017, Vol 5, Issue 2
Abstract
Background Thyroid hormones have significant effects on lipid metabolism and homocysteine levels. Decrease in thyroid hormone levels may alter the homeostasis of lipid metabolism and homocysteine levels. Objectives To study the incidence of hyperhomocysteinemia and hypercholesterolemia in patients with hypothyroidism, and to find out the correlation of homocysteine with cholesterol levels, thyroid hormones and thyroid-stimulating hormone (TSH) in newly detected hypothyroid patients. Methods In this prospective case-control study, 30 hypothyroid patients (case group) and 30 euthyroid controls were included. Patients with a TSH level >4.78 mIU/mL were considered in the case group and those with TSH level <4.78 mIU/mL were included in the control group. Cases and controls were matched on the basis of age, sex, and body mass index. Levels of TSH, free T3 andT4, fasting serum homocysteine, and total cholesterol were investigated in both case and control groups. The data were statistically analysed with Independent t-test and Pearson’s correlation method by SPSS 20.0. Results Compared to controls, significant increase in serum homocysteine levels was observed in in hypothyroid group (P = 0.0064). Serum total cholesterol levels were significantly higher in hypothyroid group when compared with control (P = 0.0066). Correlation of serum homocysteine levels with the levels of TSH, free T3 and T4, and serum cholesterol levels were statistically not significant in both hypothyroid group. Conclusion We observed a significant increase in levels of homocysteine and total cholesterol levels in hypothyroid group when compared with control. Hyperhomocysteinemia and increased cholesterol levels can contribute to cardiovascular risks. We recommend screening of serum homocysteine levels in hypothyroid patients to detect atherosclerosis and cardiovascular diseases.
Authors and Affiliations
Dr. Anjali R
Keywords
Related Articles
- EP ID EP419004
- DOI -
- Views 63
- Downloads 0
A Questionnaire based Survey on Awareness of Clinical Trials among General Population.
The aim of the questionnaire based survey was to find the extend of awareness of clinical trials among general population among the different category of people in Chennai. The project was carried out among the general...
Prevalence of low back pain in postnatal mothers who have undergone LSCS
The purpose of this study is to find prevalence of low back pain in postnatal mothers who have undergone LSCS. Retrospective study was carried out in Dr. Ulhas Patil Medical College & Hospital with 100 patient who underg...
Effect of an in service training program for intensive care nursing staff in their knowledge and practice - khartoum state 2014-2017
Background Cardiopulmonary resuscitation is the emergency procedure used to salvage victims of cardiac and respiratory arrest. It should be carried out with great urgency to avoid permanent brain damage or even death tha...
Low back injuries in fast bowlers: A literature review
Background Professional fast bowlers have been found to be at higher risk of developing low back injuries than other form of cricket players. The most common injuries related to bowling are overuse injuries to the back....
Added effects of myofascial release on pain and disability in chronic mechanical low back pain
Objectives To study to find the added effects of myofascial release on pain and disability in Chronic Mechanical Low Back Pain. Methods The sample 40 was screened, of which 30 meeting the inclusion criteria were selected...