The Diagnostic Power of the Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Biochemical Recurrence After Primary Curative Treatment in Patients with Prostate Cancer: A Single-center Experience
Journal Title: European Archives of Medical Research - Year 2019, Vol 35, Issue 4
Abstract
Objective: Our study aimed to investigate the efficacy of Gallium-68 (68Ga) prostate-specific membrane antigen (PSMA) positron emission tomography-computed tomography (PET-CT) in terms of focus detection in the presence of biochemical recurrence (BCR) after primary curative treatment in patients with prostate cancer (PCa). Methods: This study included 34 PCa patients who underwent 68Ga-PSMA PET-CT for BCR following radical prostatectomy (RP) or primary curative radiotherapy (RT), between August 2017-December 2018 at Okmeydanı Training and Research Hospital, Clinic of Nuclear Medicine. Results: Thirteen patients (38.2%) had RP and 21 (61.8%) had RT. PSMA-positive lesion was detected in 21 (61.7%) of 34 patients. PSMA positive lesion was present in six of 13 patients (46.1%) in the RP group and 15 of the 21 patients (71.4%) in the RT group. There was a PSMA-positive lesion in five out of 13 patients with serum prostate-specific antigen (PSA) values of 0.01-1 ng/mL, in five of eight patients with serum PSA values of 1-2 ng/mL, in four of five patients with serum PSA values of 2-5 ng/mL, and in seven of eight patients with serum PSA values of >5 ng/mL. PSA levels of PSMA-positive patients were found to be significantly higher than those of PSMA-negative, whereas PSA-positive and negative patients did not differ significantly in terms of PSA doubling time, time to BCR, and Gleason score. Conclusion: 68Ga-PSMA PET-CT is an effective method in the diagnosis of BCR after primary curative treatment in PCa patients.
Authors and Affiliations
Sevda Sağlampınar Karyağar, Selvi Tabak Dinçer
Keywords
Related Articles
- EP ID EP675914
- DOI 10.4274/eamr.galenos.2019.02418
- Views 129
- Downloads 0
Evaluation of Dynamic Hyperinflation with Negative Expiratory Pressure Method in Patients with Chronic Obstructive Pulmonary Disease
Objective: Chronic Obstructive Pulmonary disease (COPD) is a disease characterized by progressive airflow limitation, which is not fully reversible. Expiratory flow limitation (EFL) is the most common cause of dynamic hy...
New Developments in Oncological Treatment: Targeted Treatments and Immunotherapy
In the last 20 years, when we started to understand cancer biology better, targeted therapies and immunotherapies have been developed in systemic treatments and they have started to take their place as monotherapy or com...
Effect of Epidermal Growth Factor on Osteosarcoma Cell Proliferation and Bcl-2 Gene Expression
Objective: The aim of this study was to investigate the effects of epidermal growth factor (EGF) on osteosarcoma cell proliferation and Bcl-2 expression. Methods: In this study, MTT test was first applied to determine t...
Cornelia de Lange Syndrome with Hypernatremia: Two Case Reports
Cornelia de Lange syndrome (CdLS), is a genetical syndrome which can be seen as hereditary, or sporadically. Characteristical appearance is very crucial for diagnosis. Although almost all patient shave characteristical f...
Added Value of SPECT/CT to Whole Body Scan Test Planar Imaging in Patients with Thyroid Cancer After Radioiodine 131 Therapy
Objective: The aim of this retrospective study was to determine added value of single photon emission computed tomography (SPECT)/computed tomography (CT) imaging to whole body scan (WBS) planar imaging in patients with...