The Discovery of Insulin and the Future for Insulin Replacement Therapy
Journal Title: International Journal of Clinical Pharmacology & Toxicology(IJCPT) - Year 2012, Vol 1, Issue 1
Abstract
Adequate consumption of antioxidants, such as vitamin E, is thought to be essential for optimal health. Nutritional surveys have shown below optimal levels of vitamin E intake for adults in the United States despite a variety of dietary sources available. Fortified breakfast cereal is marketed to provide up to 100% of the daily value for several vitamins and minerals, including vitamin E, a known shortfall nutrient. The aim of the study was to determine the effect of consuming a 1-ounce serving of fortified breakfast cereal on vitamin E dietary intake as well as serum tocopherol concentrations among healthy adults. Forty-two adults completed a 6-week randomized, controlled, parallel-arm, open-label design (2-week usual diet run-in period followed by a 4-week control versus treatment period). The control group (n= 21) consumed and recorded their usual diet while the intervention group (n= 21) consumed and recorded their usual diet with the addition of a 1-ounce serving of fortified breakfast cereal during the 4-week treatment period. Diet diaries for the 6-week study period were assessed for accuracy and analyzed using Nutrient Data System for Research version 2010. Dietary and serum vitamin E (alpha-tocopherol) levels were determined. Mean total vitamin E dietary intakes at baseline were 8.0 + 5.5 mg for the intervention group and 7.8 + 4.8 mg for the control group. Total vitamin E dietary intakes increased in the intervention group to 19.5 + 5.1 mg at weeks 3 & 4 and 19.7 + 4.3 mg at weeks 5 & 6 (P<.001; P<.001) while the control group intake remained unchanged. Mean serum alpha-tocopherol levels were 0.42 + 0.31 mg/dL in the control group and 0.41 + 0.16 mg/dL in the intervention group at the baseline period. Total vitamin E dietary intakes, but not serum alpha-tocopherol, increased following the 4 weeks of fortified breakfast cereal consumption.
Authors and Affiliations
Sompop Bencharit
Keywords
Related Articles
- EP ID EP194401
- DOI 10.19070/2167-910X-120001e
- Views 103
- Downloads 0
Toxicity and Anxiolytic Property of Nettle in Mice in Light/Dark Test
Background: Anxiety is an unpleasant state of inner turmoil often accompanied by cognitive, somatic, emotional, and behavioral components. There is some evidence in traditional medicine for the effectiveness of Urtica ur...
Degradation Pathway for Rilpinavir Hydrochloride by Validated Stability Indicating UP-LC Method
Degradation pathway for Rilpivirine Hydrochoride is established as per ICH recommendations by validated and stability indicating reverse phase liquid chromatographic method. Rilpivirine Hydrochoride is subjected to stres...
Gender based Dosing of Metoprolol in the Elderly using Population Pharmacokinetic Modeling and Simulations
Introduction: This article seeks to clarify if gender-based differences occur in the pharmacokinetics of metoprolol in the elderly patients. There are a series of physiologic changes that occur in the elderly ranging fro...
PPAR α/γ Agonist in Management of Diabetic Dyslipidemia: A Review
Cardiovascular diseases are major contributors of mortality and morbidity in patients with type 2 diabetes mellitus (T2DM), while dyslipidemia and hyperglycemia are key modifiable risk factors to prevent coronary artery...
Iron Chelating and Antioxidant Activities and Cytotoxicity Effect of the Pistachio (Pistachio vera L.) hull and kernel Extracts in the A549, HT29 and MCF-7 Cancerous Cell lines
Synthetic iron-chelators have been considered for treatment of some clinical situations such as iron overloading and cancer. However, their side effects and incomplete effectiveness limit their usages. Natural products c...