Abstract

Aim The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia. Material and Method Forty-two pylori infected patients were evaluated for the status of atrophic gastritis and intestinal metaplasia. Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months aſter the helicobacter pylori eradication therapy. Helicobacter pylori status was determined by C-urea breath test 2 and 6 months aſter for helicobacter pylori eradication. Severity of gastric atrophy and intestinal metaplasia was classified as mild, moderate or severe according to the updated Sydney classification. Results The scoring of gastric atrophy was found significantly decreased in helicobacter pylori eradicated group aſter 6 months, while no significant change was found in H. pylori non-eradicated group. Intestinal metaplasia wasn’t recorded as improved in neither helicobacter pylori eradicated group nor helicobacter pylori noneradicated group. Conclusion It can be suggested that reversal of atrophy and intestinal metaplasia may occur even aſter several years, so the positive effect of eradication therapy might have been even better with a longer follow-up period. The results reported here are those obtained during the 6 months period.

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