The Effect of a Combination of Swim Training and Magnesium Supplementation on Thermal Hyperalgesia in Diabetic Rats
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2017, Vol 9, Issue 4
Abstract
Objective: A question raised here as to whether exercise training combined with Mg supplementation could improve the symptoms of neuropathic pain such as the thermal hyperalgesia more effectively than either of the two alone. This study aimed to investigate the combined effect of swim training and Mg supplementation on thermal hyperalgesia in streptozotocin (STZ) induced diabetic rats. Materials and Methods: Male wistar rats were randomly assigned to 5 groups: Control (C), Diabetic Control (CD), Training Diabetic (TD), Magnesium (Mg) Supplementing Diabetic (MgD), and Mg Supplementing and Training (MgTD). The training rats were subjected to forced-swimming for 8 weeks. Mg supplementing groups orally received magnesium sulfate (10 g/l) added into drinking water, for 8 weeks. Tail flick latency (TFL) test was used to evaluate the thermal pain threshold. Data were analyzed via multiple analyses of variance (MANOVA) Results: Diabetes displayed the thermal hyperalgesia in most of diabetic groups at the late stage diabetes (P<0.05). Long term implementation of either swim training or Mg supplementation alone improved the severity of hyperalgesia (P<0.05). The combination of swim training and Mg administration prevented the occurrence of the hyperalgesia over the course of experiment (P<0.05). Conclusion: These results suggested that the swim training go along with Mg administration could be a safe effective strategy for the prevention of painful diabetic neuropathy.
Authors and Affiliations
Saeed Daneshyar, Hadi Koochakkhani, Javad Almasi, Yazdan Forutan
Keywords
Related Articles
- EP ID EP636085
- DOI -
- Views 67
- Downloads 0
The Effect of Resistance Exercise on Blood Glucose, Insulin and Insulin Resistance in Iranian Patients with Type II Diabetes: A Systematic Review and Meta-Analysis
Objective: Resistance exercise is recommended as effective treatments for people with type 2 diabetes. However, the impact of this mode of exercise on blood glucose, insulin and insulin resistance in Iranian's type 2 dia...
The prevalence of Cognitive Impairment in Patients with Type II Diabetes and its Relationship with Quality of Life, Self-Management Profiles, and HbA1c
Objective: Diabetes mellitus (DM) is a common metabolic. One of the unknown complications of DM is cognitive disorders. Different types of cognitive impairment caused by DM may affect the quality of life, self-management...
The Effect of 12 Weeks Aerobic Training on the Mafa Gene Expression of Pancreas in the Male Wistar Rats Type 2 Diabetes
Objective: MafA is one of the major factors in the family of MafA transcription factors. In pancreatic beta cells, MafA plays an important role in regulating the expression of glucose-dependent Insulin gene. On the other...
The Effect of 6 Weeks Resistance Training and HITT on GLP-1 Gene Expression of Diabetic Rats
Objective: Cardiovascular diseases are the main reason of the death in type 2 diabetic patients. The purpose of this study was to evaluate the effect of 6 weeks of resistance training and HITT (High Intensity Interval Tr...
The Effects of Flaxseed on Weight Loss in Women with Polycystic Ovarian Syndrome: a Randomized Controlled Trial
Objective: The aim of this study was to evaluate the effectiveness of flaxseed consumption in improving weight loss and altering anthropometric indices in overweight and obese women with polycystic ovary syndrome (PCOS)....