The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2017, Vol 11, Issue 5
Abstract
Background and Objectives: Diabetes is one of the most important metabolic diseases, which its incidence rate has increased in recent years. In this disease, the insulin function is impaired, leading to several complications. Physical exercise and medicinal plants are considered as a way to control diabetes along with nutrition and medicine. The present study was conducted with the purpose of determining the effect of aerobic training and use of arbutin on cardiac nitric oxide, tumor necrosis factor-α and vessel endothelial growth factor in male diabetic rats. Methods: In this experimental study, 42 male adult Wistar rats (age, 8 weeks; weight, 190-220g), were randomly divided into 6 groups of 7 each (control, arbutin, diabetic, diabetic+training, diabetic+arbutin, and diabetic+training+arbutin). Training programs included 5 days of swimming per week for 6 weeks. Sampling from the heart was performed 72 hours after the last training session and arbutin consumption to analyze NO, TNF-α and VEGF. Data were analyzed using one-way ANOVA at the significance level p≤0.05. Results: Aerobic training along with use of arbutin led to increased levels of NO and VEGF and decreased level of TNF-α in cardiac tissue of diabetic rats (p<0.001). Conclusion: The results indicated that a period of regular aerobic training and use of arbutin can be considered as an appropriate non-medicinal method to control diabetes mellitus type 2 through decrease in inflammatory factors.
Authors and Affiliations
Rahemeh Jahangiri Rahemeh Jahangiri, Parvin Parvin, Masoumeh Habibian Masoumeh Habibian
Keywords
Related Articles
- EP ID EP464738
- DOI -
- Views 68
- Downloads 0
Evaluation and Identification of Carbapenem Resistant Klebsiella pneumoniae Isolated from Hospitalized Patients in Qom City, (Iran)
Background and Objectives: Klebsiella pneumonia is a facultative anaerobe bacterium from enterobacteriaceae family, which causes a wide range of diseases, such as urinary tract infections, cystitis, pneumonia, surgical w...
Evaluation of CTX-M-1 Beta Lactamase Gene in Escherichia coli Isolated from the Urine Tract Infections of Patients by PCR Method
Background and Objectives: Pathogenic bacteria, such as Escherichia coli are dangerous for human population due to acquisition of resistance genes to beta-lactam antibiotics. This resistance is due to extended spectrum β...
Effect of Consumption of Honey Containing Bacillus coagulans on Inflammatory and Oxidative Stress Factors in Patients with Diabetic Nephropathy
Background and Objectives: Diabetic nephropathy is one of the dangerous complications of diabetes, which has a relatively high incidence in diabetic patients and causes kidney failure. The aim of this study was to invest...
شناسایی مقاومت القایی به کلیندامایسین در سویه‌های استافیلوکوکوس اورئوس جدا‌شده از بیماران بستری در بیمارستان‌های شهر تهران
زمینه و هدف: ظهور سویه‌های مقاوم به آنتی‌بیوتیک باکتری استافیلوکوکوس اورئوس، چالش بزرگی در درمان عفونت‌های ناشی از این باکتری ایجاد کرده و مقاومت القایی به کلیندامایسین نیز موجب نقص درمان شده است. این مطالعه با هدف شناسا...
تأثیر عصاره هیدروالکلی تاماریکس دیوکا بر تغییرات هیستوپاتولوژیک کبد در موش‌های صحرایی تغذیه‌شده با جیره پرچرب
زمینه و هدف: تاماریکس دیوکا، گیاه دارویی منطقه بلوچستان است که اثرات آنتی‌اکسیدان و ضددیابتی دارد. این پژوهش با هدف تعیین تأثیر عصاره هیدروالکلی این گیاه بر آسیب کبدی ناشی از جیره پرچرب انجام شد. روش بررسی: در این مطالعه...