The effect of alkylpolyglycoside surfactants on the crystallization of spray-dried salbutamol sulphate: a gravimetric near-infrared spectroscopy study
Journal Title: The AAPS Journal - Year 2002, Vol 4, Issue 3
Abstract
This study monitored the effect of a series of structurally related surfactants on the crystallization of amorphous salbutamol sulphate. Amorphous salbutamol sulphate was prepared by spray drying from a solution in water and in the presence of various alkylpolyglycosides (APGs) at different concentrations. The particles were then analyzed using isothermal microcalorimetry and water vapor sorption (Dynamic Vapour Sorption, DVS) analysis combined with near-infrared spectroscopy (DVS-NIR). Both isothermal microcalorimetry and DVS-NIR were able to detect the transition from the amorphous to the crystalline state. The presence of APG surfactants modified the shape of the crystallization peak obtained using isothermal microcalorimetry. The gravimetric study combined with NIR revealed that while the crystallization was similar for the particles with or without surfactant, there was a great difference in the release of water from the newly formed crystal. In the presence of some of the surfactants tested, salbutamol sulphate released the water much faster than in the absence of surfactant. These results helped to explain the differences found in the isothermal microcalorimeter data. Differences were observed in the shapes of the NIR water peaks related to water due to the presence of the surfactant. In conclusion, the use of DVS combined with NIR has helped to analyze and understand the effect of APGs on the crystallization of amorphous salbutamol sulphate.
Authors and Affiliations
Angela Columbano, Graham Buckton, Philip Wikeley
Keywords
Related Articles
- EP ID EP682006
- DOI 10.1208/ps040316
- Views 86
- Downloads 0
Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs
With the increasing number of poorly water-soluble compounds in contemporary drug discovery pipelines, the concept of supersaturation as an effective formulation approach for enhancing bioavailability is gaining momentum...
Neuropeptide-processing enzymes: Applications for drug discovery
Neuropeptides serve many important roles in communication between cells and are an attractive target for drug discovery. Neuropeptides are produced from precursor proteins by selective cleavages at specific sites, and ar...
Role of Public Standards in the Safety and Efficacy of Biologic Medicines
In this report, we emphasize the importance of public monographs with reference materials, coupled with careful process and change control and attention to GMPs, as a means of advancing access to good quality, safe, and...
Using DTA and DTAARRAY Variables and Programming in WinNonlin ASCII Models to Streamline User-Defined Calculation and Data Analysis
The online version of this article (doi:10.1208/s12248-014-9711-7) contains supplementary material, which is available to authorized users.
Summary Workshop Report: Bioequivalence, Biopharmaceutics Classification System, and Beyond
The workshop “Bioequivalence, Biopharmaceutics Classification System, and Beyond” was held May 21–23, 2007 in North Bethesda, MD, USA. This workshop provided an opportunity for pharmaceutical scie...