The Effect of Alpha Crystallin on Diet Induced Hypercholstrolemic Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 6
Abstract
To explore the effect of bovine -crystallin on high cholesterol diet-induced rats. Rats were divided into three groups (n=6 in each) control, hypercholesterolemic and crystallin treated. The lipid profiles, antioxidant and membrane bound ATPase status of serum and various tissues were investigated in hypercholesterolemic rats and the effect of -crystallin on defense systems. The results showed that there was a decrease in cholesterol, triglyceride level on -crystallin treated hypercholesterolemic rats. Cholesterol enriched diet caused a significant increase in the lipid peroxide and free radical scavenging enzyme concentrations of serum, liver and heart. In addition, a significant decrease in glutathione (GSH) content, were found in serum, liver and heart. This study indicated that administration of -crystallin may play an important role in suppressing oxidative stress, and thus, may be useful for the prevention of hypercholesterolemia.
Authors and Affiliations
S. Nirmala Bharathi, R. Jayakumar* 1,
Keywords
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