The effect of citrus flavanones on the redox homeostasis in cells exposed to oxidative stress – studies in vitr
Journal Title: Medycyna Środowiskowa - Environmental Medicine - Year 2016, Vol 19, Issue 2
Abstract
Introduction: Flavanones (an important group of antioxidants in citrus fruits) are beneficial for health, which is connected with their anti-inflammatory, anti-atherogenic and anti-carcinogenic properties. The present study was undertaken to investigate whether – and in what way – the presence of flavanones influences the redox homeostasis of fibroblasts and alleviates the effects of oxidative stress. Material and methods: The study was conducted on murine fibroblast cell cultures with the addition of flavanones (hesperidin, hesperetin, naringin, naringenin), exposed to oxidative stress (Fe/Asc). In cell homogenates, the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) was measured; in the medium, the concentration of nitric oxide was measured. Results and conclusion: Our results demonstrate that the addition of naringenin, hesperetin, naringin and hesperidin has a protective effect on cells subjected to oxidative stress The changes observed are particularly visible in the case of aglycone forms of both compounds. Despite the protective properties against oxidative stress which flavanones display, we determined distrubances in redox homeostasis in comparison to the control culture.
Authors and Affiliations
Ewa Kurzeja, Agnieszka Synowiec-Wojtarowicz, Katarzyna Spiołek, Małgorzata Derewniuk
Keywords
Related Articles
- EP ID EP206662
- DOI -
- Views 123
- Downloads 0
Narażenie na ołów a stężenie we krwi kadmu, selenu i wartości morfologii
Wstęp. Metale ciężkie, w tym kadm i ołów, zalicza się zarówno do trucizn środowiskowych jak i przemysłowych, powodujących zaburzenia procesów metabolicznych. Skutki oddziaływania tych pierwiastków są zwykle odległe i dłu...
Environmental risk factors in autoimmune diseases: a review of literature
Autoimmune diseases are a very common group of disorders, with prevalence rate over 5%–8% in the general population. The etiology of autoimmune diseases is very complex. It is considered that they are caused by a combina...
Personal Exercise Behavior and Attitudes Towards Physical Activity Among Physiotherapy Students
Introduction. This study was designed to obtain information about the personal exercise behavior and to evaluate the relationship between attitudes towards physical activity and personal exercise practices of future phys...
The assessment of neonates’ exposure to traumatic factors in the cardiac ward within the first 24 hours of hospitalization
Introduction: During the first 24 hours of hospitalization, neonates with ductus-dependent CHD are exposed to a number of traumatic impulses arising from the need for necessary care and therapeutic procedures. Material a...
Ocena jakości powietrza wewnątrz budynku szkolnego. Studium przypadku z Wrocławia
W celu osiągnięcia dobrej jakości powietrza w szkole, gdzie dzieci spędzają ok. 6–8 godzin dziennie i znalezienia rozwiązania, by ją poprawić, należy dokładnie rozpoznać problem zanieczyszczenia powietrza wewnętrznego. D...