The Effect of Co-administered Drugs and Food on the Absorption of Artemether–Lumefantrine Tablet
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2015, Vol 2, Issue 4
Abstract
The physicochemical properties of drugs, their dosage forms and routes of administration affect the rate and extent of drug absorption. Oral administration of drugs presents with variable absorption profiles due to multifarious factors. The first fixed-dose artemisinin-based combination therapy (ACT), artemether-lumefantrine widely employed for the treatment of uncomplicated Plasmodium falciparum malaria is being threatened by the report of rapidly developing drug resistance in some part of the world. Success from this therapy has been linked to the synergistic effect of the component drugs which is anchored on the artemether and more importantly, lumefantrine exposure. The drug and food effect on the pharmacokinetic profiles of artemether and lumefantrine antimalarial agents are reviewed.
Authors and Affiliations
Sunday O. Awofisayo, Augustine O. Okhamafe
Keywords
Related Articles
- EP ID EP342675
- DOI 10.9734/JAMPS/2015/15333
- Views 92
- Downloads 0
The Effect of Co-administered Drugs and Food on the Absorption of Artemether–Lumefantrine Tablet
The physicochemical properties of drugs, their dosage forms and routes of administration affect the rate and extent of drug absorption. Oral administration of drugs presents with variable absorption profiles due to multi...
Antiretroviral Therapy Contribution to Patients Health in New Juaben Municipality
Our study focused on identifying factors underlining the deteriorating health condition of people living with HIV/AIDS (PLWHA) in the New Juaben Municipality. After a review of the relevant literature, the following hypo...
Decreased Serum Magnesium Level among Nigerian Women with Late Onset Pre-eclampsia
Background: Pre-eclampsia is a common medical complication of pregnancy associated with increased maternal and perinatal mortality and morbidity. Its etiology is unknown, although several evidences indicate that deficien...
A Practical Approach for Restoring Homeostasis in Diseases Characterized by a Chronic Oxidative Stress
The leading cause of death across the globe is due to cardiovascular diseases complicated by a chronic oxidative stress only partially corrected with orthodox drugs. About 80% of deaths occur in low and middle-income cou...
MicroRNA Memory I: The Positive Correlation between Synergistic Effects of MicroRNAs in Cancer and a Novel Quantum Scoring System
Aim: To investigate quantum characters of the microRNA (miRNA) gene as the disease memory device, at the beginning, a novel quantum scoring method was developed and its usability was confirmed by valuating miRNA–miRNA in...