The Effect of Framingham Score on the Oncological Outcomes in Localized (T1-T2 Stage) Renal Cell Carcinoma Patients
Journal Title: Üroonkoloji Bülteni - Year 2019, Vol 18, Issue 2
Abstract
Objective: To evaluate the effect of cardiovascular disease risk on local recurrence, distant metastasis development and cancer-specific survival in patients with localized (stage 1 and 2) renal cell carcinoma (RCC). Materials and Methods: Data of patients who underwent partial or radical nephrectomy due to pathological stage 1 and 2 RCC between September 2009 and July 2016 were retrospectively evaluated. Ninety-six patients with fully accessible data were included in the study. Demographic data, histological tumor type, Fuhrman grading, local recurrence, metastasis and survival after nephrectomy were recorded. Framingham risk score, which predicts cardiovascular disease within 10 years, was calculated in all patients. The patients were divided into three groups as low (group 1), moderate (group 2) and high risk (group 3). Results: Mean age of patients was 58.66±10.55 years at the time of nephrectomy. Nine (9.4%) patients had local recurrence, 12 (12.5%) had distant metastasis and 11 (11.5%) died due to cancer during a median follow-up period of 57 (6-102) months. Regarding intergroup comparison, local recurrence rate (21.9%, p=0.012) and distant metastasis rate (25%, p=0.025) were significantly higher in group 3, and predicted recurrence-free survival (66.4 months, p=0.005), metastasis-free survival (77 months, p=0.017) and cancer-specific survival (79.9 months, p=0.024) were found to be significantly lower. In univariate analysis, body mass index, total cholesterol level, estimated glomerular filtration rate and Framingham risk score were independent predictive factors for local recurrence, distant metastasis development and cancer-specific survival. In multivariate analysis, body mass index, estimated glomerular filtration rate and Framingham risk score were more significant. Conclusion: Patients who are at high risk of developing cardiovascular disease have more local recurrence, distant metastasis and cancer-specific mortality rates, even though nephrectomy is performed due to localized RCC. Therefore, we suggest that these patients should be followed more carefully in the post-nephrectomy period.
Authors and Affiliations
İsmail Selvi, Halil Başar
Keywords
Related Articles
- EP ID EP588910
- DOI 10.4274/uob.galenos.2018.1164
- Views 128
- Downloads 0
Evaluation of the Relationship Between Duration of Smoking and Clinical and Pathologic Characteristics of Bladder Cancer at Diagnosis
Objective In this study, we aimed to evaluate the relationship between the duration of smoking and clinical and pathological characteristics of malignant bladder cancer at diagnosis. Materials and Methods In this study,...
Preoperative Factors Related to Stage and Grade Increase in D’Amico Low-Risk and Intermediate-Risk Group Patients
Objective: In this study we searched preoperative factors that may cause upstaging and upgrading at D’Amico low-risk and intermediate-risk group patients who underwent radical prostatectomy (RRP) due to prostate adenocar...
Metastasis Targeted Therapies in Renal Cell Cancer
Metastatic renal cell cancer is a malignant disease and its treatment has been not been described clearly yet. These patients are generally symptomatic and resistant to current treatment modalities. Radiotherapy, chemoth...
Positron Emission Tomography in Renal Cell Carcinoma
Renal cell carcinoma is the most common solid kidney tumor. Conventional methods such as computed tomography and magnetic resonance imaging are usually chosen for diagnosis, staging, and evaluating recurrence and treatme...
Incidental Amyloidosis of the Seminal Vesicle: A Case Report and Review of the Literature
With a widely usage of prostate specific antigen (PSA) testing as a screening tool, number of prostate biopsy procedures and number of biopsy cores are increased because of the negative pathology results. As a result of...