The effect of regular moderate exercise, on cardiac hypertrophy and blood glucose level in diabetic adult male rats
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2013, Vol 6, Issue 4
Abstract
Diabetes mellitus comprises a group of common metabolic disorders that hyperglycaemia is the common phenotype of its. Although, insulin and other glucose-lowering drugs are the most common method for treating diabetes, but also beneficial effects of exercise in regulating glucose metabolism, have been proved. Considering the effective role of exercise in diabetic patients, in this study the impact of different periods of regular moderate exercise on cardiac hypertrophy and blood glucose level were examined, to presenting a suitable pattern of exercise for diabetic patients. 60 male Wistar rats (300?50g) were randomly divided into six groups (n=10): sedentary control, control with fifteen day exercise, control with sixty day exercise, sedentary diabetic , diabetic with fifteen day exercise and diabetic with sixty day exercise. Diabetes was induced by injection of streptozotocin (60 mg/Kg). The treadmill exercise 5 days a week for an hour with 22 (m/min) speeds were begun, a week after induction of diabetes. The results of this study showed that the mean blood glucose level is significantly decreased (P<0/05) by increasing the day of exercising. And also, regular moderate exercise has prevented cardiac hypertrophy that was observed in the sedentary diabetic group. The fifteen day regular moderate exercise was not significantly reduced the blood glucose and by continuing it, blood glucose was closer to normal. Also, this type of exercise, was prevented from hypertrophy of the heart that caused by diabetes.
Authors and Affiliations
Farzam Sheikhzadeh| Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. email: Fsheikhzadeh@tabrizu.ac.ir, Nazli Khajehnasiri| Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Department of Biology, Faculty of basic Sciences, Rab- Rashid Higher Education institute, Tabriz, Iran., Seyed Mahdi Banan Khojasteh| Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran., Farhad Ghadiri Soufi| Molecular medicine research center, Hormozgan University of Medical Sciences, Bandar-Abbas, Iran, Ali Dastranj| Women's Reproductive Health Research center, Tabriz University of Medical Sciences, Tabriz, Iran., Majid Taati| Department of Physiology, Faculty of Veterinary, University of Lorestan, Lorestan, Iran.
Keywords
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