The Effect of Tumor Size on Oncologic Outcomes in Pathological T2 Stage Renal Cell Carcinoma Patients
Journal Title: Üroonkoloji Bülteni - Year 2017, Vol 16, Issue 1
Abstract
Objective: To evaluate the oncologic outcomes in T2 stage renal cell carcinoma (RCC) patients who underwent open radical nephrectomy and the effect of patient’s tumor size on the oncologic outcomes. Materials and Methods: Data of patients who underwent open radical nephrectomy due to pre-diagnostic RCC between January 2010 and January 2014 and had the tumor size >7 cm were retrospectively evaluated. Two hundred thirty six patients with final pathologic diagnosis of RCC were included in the study. Patients were divided into two groups according to their tumor sizes (≤10 cm and >10 cm). The data of demographics, histological tumor subtype, tumor grade, survival after nephrectomy, local recurrence and metastasis were recorded. Results: Mean age and mean tumor size of patients at diagnosis were 58±11.5 years (28-80) and 10.4±2.6 cm (7.1-20), respectively. Out of 236 patients included in the study tumor size were ≤10 cm (group 1) in 120 patients and >10 cm (group 2) in 116 patients. After median 36 (16-176) months follow up time, local recurrence, distant metastasis, disease specific survival and overall survival rates of the patients were 19.4%, 7.6%, 82.6% and 77.6%, respectively. When the two groups were compared; patients in group 1 were determined to have significantly higher disease specific survival (89% vs. 75%, p=0.007), higher overall survival rate (86% vs. 81%, p=0.001), lower local recurrence rate (13% vs. 25%, p=0.023) and lower local distant metastasis rates (5% vs. 12%, p=0.01). Conclusion: In patients whose tumor sizes are larger than 10 cm, lower disease specific survival and overall survival, higher local recurrence and distant metastasis rates were observed. Therefore, those patients should be followed more carefully after nephrectomy.
Authors and Affiliations
Nurullah Hamidi, Evren Süer, İlker Gökçe, Yaşar Bedük, Sümer Baltacı
Keywords
Related Articles
- EP ID EP226733
- DOI 10.4274/uob.780
- Views 84
- Downloads 0
The Relationship between Bladder Cancer and Epigenetic Alterations
Bladder cancer is one of the most common cancers of urinary system and approximately 70% of the cases are low grade and non-muscle invasive. Because of the histological indicator inadequacy of heterogeneous tumors like b...
Early and Late Complications of Urinary Diversions after Radical Cystectomy
One of the strongest predictive factors for the early and late postoperative complications and morbidity of radical cystectomy is the type of urinary diversion following cystectomy. In this paper, we reviewed English-lan...
Vascular Ligation in Laparoscopic Radical Nephrectomy: Comparison of the Endo GIA Stapler and Hem-o-lok Polymer Clips
Objective: Various techniques for vascular ligation are used during laparoscopic surgery. We aimed to compare the Endo GIA stapler and Hem-o-lok polymer clips in laparoscopic radical nephrectomy. Materials and Methods: T...
A Rare Tumor: Prostate Neuroendocrine Carcinoma Case Report
Neuroendocrine prostate cancer is very rare disease with high mortality. It is one of the most commonly observed extrapulmonary small cell lung cancer types. In this case report we wanted to indicate how aggressive can n...
Prostatic Carcinosarcoma: A Case Report
Prostatic carcinosarcoma is a rare malignancy composed of sarcomatous and carcinomatous elements. Predominantly, they are very aggressive tumors with a poor prognosis. In this case report, a 78 year-old male patient with...