THE EFFECTIVENESS OF TIGECYCLINE IN MULTIDRUG RESISTANT INFECTIONS IN INTENSIVE CARE UNIT
Journal Title: International Journal of Medicine and Pharmaceutical Sciences (IJMPS) - Year 2017, Vol 7, Issue 3
Abstract
Background Infection with multidrug resistant (MDR) organism represent an important cause of a poor patient outcome, prolonged hospitalization and mortality. Patients in the intensive care unit at increased risk of developing these infections. Aim To evaluate the activity of tigecycline on MDR infection and to assess patient outcome. Patients and Methods Eleven patients, admitted to the intensive care unit at Ghazi Al-Hariri surgical hospital for the period from (Febuary 2016 to May 2016) whom infected with (MDR) organism documented by culture and sensitivity test results, received intravenous tigecycline and were assessed for outcome were included in the study. Results All the enrolled patients had infection resistance to the available antibiotics, the isolated (MDR) organisms were Klebsiella spp. (46%), Acinetobacter spp. (45%), and Enterobacteriace spp. (9%), causing sepsis in 60% and intra-abdominal infection in 40% of patients. Tigecycline was given at a median loading dose of (100mg), followed by a median maintenance dose of 50mg twice daily (100mg/day) for a median duration of (16 day. It was associated with better patient outcome (91%), discharged well from the hospital with median hospitalization periods of (1.4 month) and mortality of (9%). Conclusion Tigecycline was effective against (MDR) infection encountered in the ICU and was associated with better patient outcome.
Authors and Affiliations
WALEED IBRAHEEM ALI AL-ANSARI, ALI SHAWKI, THURA HIKMAT ABDUL-WAHHAB
Keywords
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- EP ID EP226003
- DOI 10.24247/ijmpsjun20172
- Views 145
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