The Effects of Endurance Training and Gallic Acid on BDNF and TNF-a in Male Rats with Alzheimer
Journal Title: International Journal of Applied Exercise Physiology - Year 2016, Vol 5, Issue 4
Abstract
Background: In the present study, the effects of endurance training and chronic administration of Gallic acid (GA) on hippocampal level of brain-derived neurotrophic factor (BDNF) and tumor necrosis factor alpha (TNF-α) in trimethyltin (TMT)-induced hippocampal degeneration as a model of Alzheimer’s disease were investigated. Methods: 70 male Sprague-Dawley rats were selected and randomly assigned to 7 groups: 1.control, 2.TMT, 3.TMT+GA50, 4.TMT+GA100, 5.TMT+Ex, 6.TMT+Ex+GA50, 7.TMT+Ex+GA100. For induction of Alzheimer's disease, the rats in groups 2-7 were injected with single dose of TMT (8 mg/kg), intra-peritonealy (i.p.). Rats in the groups 5, 6 and 7 carried out an 8-week exercise program on a motorized treadmill (15-20 m/min, 0% inclination for 15- 30 min/day, 5 days/week). In addition, the groups 3 and 6 were treated by 50 mg /kg and groups 4 and 7 are administered 100 mg/ kg of Gallic acid for 2 weeks. Then, the hippocampal level of BDNF and TNF-α was performed for all groups by Elisa. Results: The findings of present study showed that the hippocampal level of BDNF in all test groups are significantly higher than TMT group (p≤0.05) and the hippocampal level of TNF-a in all test groups is significantly less than the TMT group (p≤0.05). Conclusion: Endurance exercises training, chronic administration of GA and co-treatment with training and GA consumption specially, having sufficient neurotrophic and immune modulator effects in male rats with Alzheimer.
Authors and Affiliations
Mohammad Amin Edalatmanesh, Yoones Baziyar, Seyed Ali Hosseini, Abdossaleh Zar
Keywords
Related Articles
- EP ID EP567946
- DOI -
- Views 66
- Downloads 0
The effect of 8-week low impact aerobic exercise on plasma fibrinogen concentration in old women
Applied Exercise Physiology focuses on the physiological effects of exercise training on physiological processes, health, and physical well-being. The aim of this study was investigation of effects of 8-week low impact a...
Psychophysiological features of athletes practicing different styles of martial arts - the comparative analysis
Study aim. The aim of the research is a comparative analysis of psychophysiological features of athletes of practicing different martial arts. Methods. 46 elite wrestlers participated in a research were divided into thre...
Metabolic Responses to Sago and Soy Supplementations during Endurance Cycling Performance in the Heat
This study examined the effects of Sago (Sa), Soy (So), combined iso–caloric Sago+Soy (SS) supplementations during cycling on metabolic responses as compared to placebo (P) in the heat (31℃, 70% relative humidity). Twelv...
The Effect of Combination Exercise Training on Cardiovascular Risk Factors (adiponectin, interleukin-6 and homocysteine) in Sedentary Middle aged Men
Purpose: Cardiovascular diseases are the major cause of mortality in all over the world. We evaluated the effect of eight weeks combined training on some cardiovascular risk factors in sedentary healthy middle aged men....
The Examination and Comparison of Recreational Sports Centers With Regard to Quality of Service
The goal of this study is to analyses private sports centers offering recreational activities in the cities of Izmir and Manisa (Turkey) according to the opinions of voluntary members and compare them based on several va...