The Effects of High Intensity Interval Training on Mir-23a Expression and Related Factors Involved in Muscular Atrophy of Aged Rats
Journal Title: International Journal of Applied Exercise Physiology - Year 2019, Vol 8, Issue 1
Abstract
Among the epigenetical factors involved in muscular atrophy, Mir-23a is subjected to change due to an alternation in intercellular calcium levels. The aim of this study is to investigate the chronic effect of high intensity interval training (HIIT) on Mir-23a expression and some other related factors, interpreting in Plantaris muscle atrophy of aged rats. Twenty-eight aged and young rats were divided into 4 different groups including exercise and control. The training protocol included 6 weeks of HIIT. Animals were sacrificed 48 hours after the last training session, and Plantaris muscle was removed. In order to measure Mir-23a, Rcan-1mRNA, Murf-1mRNA and Atrogin-1mRNA we used Real-time PCR technique. The results showed that aging significantly decreased Mri-23a (p=0.0001) as well as Rcan-1mRNA (p=0.0001) expression as upstream factors in atrophy signaling cascade, and exercise lead to a significant increase (interaction effect) of those two factors (both p=0.003). However, exercise had no significant effect on Mri-23a (p=0.238) and Rcan-1mRNA (p=0.428) in young group. Murf-1mRNA (p=0.009) and Atrogin-1mRNA (p=0.001) were significantly increased due to aging, and exercise resulted in a significant decrease in those genes in young groups (p=0.04 and p=0.003; respectively), but not a significant interaction effect in aged groups (p=0.439 and p=0.069; respectively). It seems that HIIT could improve muscular atrophy- as a result of aging- and this happens through Calcineurin signaling factors & ROS modification.
Authors and Affiliations
Seyed Morteza Tayebi, Marefat Siahkouhian, Mohammad Keshavarz, Reza Mahdian, Mahdieh Mollanouri Shamsi, Shirin Shahbazi
Keywords
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- EP ID EP572111
- DOI 10.30472/ijaep.v8i1.347
- Views 67
- Downloads 0
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