The efficacy of cognitive rehabilitation with RehaCom programme in schizophrenia patients. The role of selected genetic polymorphisms in successful cognitive rehabilitation
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 20, Issue 1
Abstract
Introduction. Schizophrenic patients present cognitive dysfunctions which are regarded to be one of endophenotypical markers predisposing to schizophrenia. Currently, schizophrenia can be treated as a neurodegenerative and neurodeveloping disease with genetic background.Objective. Assessment of the possible positive effect of neuropsychological rehabilitation in schizophrenia, in patients presenting cognitive dysfunctions. An additional aim was to verify the hypothesis that some genetic polymorphisms can be a prognostic factor for success in neuropsychological rehabilitation.Material and methods. 41 participants and 40 control subjects were randomly selected. Both groups had the diagnosis of paranoid schizophrenia. Cognitive functions were checked with the Wisconsin Card Sorting Test, Trail Making Test, and Stroop Test at the beginning and end of the experiment. In the research group, each patient trained with the rehabilitation programme RehaCom, whereas the control group did not receive such training. Genes COMT rs4680 and BDNF rs6265 were analysed in the genetic part of study.Results. RehaCom procedures appear to be useful in the neuropsychological rehabilitation of cognitive dysfunctions in patients diagnosed with schizophrenia. The research group showed a moderate improvement in the training programmes. Analysis of parameters obtained in the neuropsychological tests showed a slight improvement in both groups. At the present time, analysis of the polymorphisms of genes cannot be treated as a prognostic factor for the success of neuropsychological rehabilitation because statistical analyses showed few dependences with little statistical significance.Conclusions. Cognitive rehabilitation produces moderate improvement in cognitive functioning.
Authors and Affiliations
Monika Mak, Jerzy Samochowiec, Piotr Tybura, Przemyslaw Bieńkowski, Beata Karakiewicz, Liliana Zaremba Pechmann, Bożena Mroczek
Keywords
Related Articles
- EP ID EP80581
- DOI -
- Views 134
- Downloads 0
Immune and clinical response to honeybee venom in beekeepers
OBJECTIVE:The aim of the study was to assess immune response to honeybee venom in relation to the degree of exposure, time after a sting and clinical symptoms.MATERIALS AND METHOD:Fifty-four volunteers were divided into...
Are cognitive functions in post-menopausal women related with the contents of macro- and micro-components in the diet?
[b]The objective[/b] of the study was an evaluation of the relationship between the level of cognitive functions and contents of micro- and macro-components in the diet of postmenopausal women. A group of 402 women was r...
The impact of economic factors on the realities of outpatient multi-drug treatment of chronic diseases in rural areas.
The reform of the health care system in Poland introduced in 1999 brought not ony a lot of disappointments arising from the failure in performing its basic assumptions, but also from the deterioration in access to medica...
Implementation of electronic health records in Polish outpatient health care clinics – starting point, progress, problems, and forecasts
[b]Introduction.[/b] The Act on Information System in Health Care, dated 28 April 2011, imposes an obligation to record patients’ medical documentation in an electronic form (EHR – Electronic Health Records) on the provi...
Sexual Education from high school students’s view – results of own research
Introduction: Sexual education is still a non-defined area concerning sexual life of man. It is perceived differently depending on country and culture. In Poland, it should be implemented as part of “Family Life Educatio...