The Efficacy of Infliximab plus Methotrexate in Patients with Active Rheumatoid Arthritis in North of Iraq: 5-Year Extended Study
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 10
Abstract
Objective: To evaluate the role of infliximab plus methotrexate given for up to 5 years in patients with active longstanding rheumatoid arthritis. Methods: patients responding inadequately to methotrexate and at least one other disease-modifying antirheumatic drug were enrolled into a 24 week, controlled study with infliximab plus methotrexate or placebo plus methotrexate and some were enrolled in a subsequent open label extension. The efficacy were evaluated. Results: Among 250 patients in the original trial, 220 received at least one dose of infliximab and were evaluated. At the time of analysis 160/ 220 (72.7%) patients had remained in the study and received treatment for a mean of 4.5 years. Withdrawals were for lack of efficacy (24%), adverse events (36%), and other reasons(50%). In 160 patients who completed 5 years treatment efficacy achieved of 6 month was maintained at 5 years. 45% achieved clinical remission (DAS28<2.6), and 27% had no physical function abnormalities (HAQ=0). Results were similar for 160 patients who received treatment for 3-5 years. Conclusions: Infliximab plus methotrexate sustained clinical response and remission in patients with rheumatoid arthritis during 5 years
Authors and Affiliations
Dr Niaz Al-Barzinji
Keywords
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