The Epidermal Growth Factor Receptor: A Potential Therapeutic Target in ChronicKidney Disease
Journal Title: Nephrology – Open Journal - Year 2017, Vol 3, Issue 1
Abstract
Chronic kidney disease (CKD) is a clinical syndrome characterized by a gradual loss of kidney function that persists for >3 months with health implications and affects nearly 500 million people worldwide. Diabetes and hypertension are the 2 most common causes of CKD, which account for up to two-thirds of the cases.1-3 Accumulating evidence has shown that hyperuricemia is tightly associated with the pathogenesis of CKD.1-4 Hyperuricemic nephropathy is a condition characterized by glomerular hypertension, arteriolosclerosis, and tubule interstitial fibrosis. Prior studies demonstrate that decreasing uric acid levels delays the development of CKD and slows its progression and uric acid is an independent predictor of future development of CKD.1-4 The mechanistic processes by which hyperuricemia induces chronic renal injury involve deposition of uric acid crystals in the collecting duct of the kidney, renal angiotension system activation, oxidative stress, tubular epithelial cell transition and inflammation.
Authors and Affiliations
Shi-Bin Cheng
Keywords
Related Articles
- EP ID EP558268
- DOI 10.17140/NPOJ3-e006
- Views 140
- Downloads 0
Depression in Dialysis
When was the last time you talked to your dialysis patient about depression? And what prompted you to start the conversation? It may be that our patients are not talking to us about the way they feel regarding the treatm...
Current Trends in Chronic Kidney Disease
Chronic kidney disease (CKD), a major contributor to health care burden, is defined by persistent indicators of renal structural and or functional abnormalities. Diabetes mellitus, hypertension, and obesity are important...
Extensive Search for Dry Weight: Should We Change the Strategy?
Introduction: A wrong estimate of the dry weight in hemodialysis patients increases their morbidity and mortality. The aim of our study was to compare the results of the estimated dry weight using the clinical examinatio...
Suggestions to Improve Medical Education in China-Learning from Diagnostic Errors of Kidney Diseases
A correct diagnosis is key to deliver the safe and effective medical interventions. However, diagnostic errors that can jeopardize patients’ safety are common in clinical settings. Herein, we analyzed diagnostic errors i...
Recent Advances in Fibro-blast Growth Factor-23 Functions
During the past decade a lot of work has been done to better understand the roles of fibroblast growth factor-23 (FGF-23); a relatively newly discovered endocrine hormone, in multiple organ systems in the body. This revi...