THE EVALUATION OF DOSIMETRIC PARAMETERS FOR PELVIC INTENSITY RADIOTHERAPY AND SIMULTANE INTEGRATED BOOST TREATMENT PLANS IN PROSTAT CANCER
Journal Title: Kocatepe Medical Journal - Year 2021, Vol 2, Issue 22
Abstract
OBJECTIVE: The aim of this study is to compare two different Conformity Index (CI), Critical organ scoring index (COSI), Tumor control probability (TCP) and Normal Tissue complication probability (NTCP) calculations, and Dose Volüme Histogram (DVH) parameters of 3 different IMRT treatment techniques in prostate cancer patients who underwent pelvic radiotherapy and prostate simultane integre boost (SIB). MATERIAL AND METHODS: In this study, a total of 20 plans with conformal radiotherapy (3DCRT) and different intensity modulated radiotherapy (IMRT) techniques were made in the treatment planning system for 5 prostate cancer patients who had been treated in our clinic. In the evaluation of plans; homogeneity index (HI), mean dose (Dmean), TCP and two different CI values were calculated for all planning target volumes (PTV). Also, DVH data, NTCP and COSI calculations for the rectum, bladder, small intestine and femoral head were found and evaluated. For normal tissue, the volume receiving half of the prescribed dose (V40Gy) and the volume receiving 90% (V72Gy) were evaluated. RESULTS: The RTOGCI mean values for PTV2 and PTV3 were significantly closer to 1 with IMRT plans when compared to 3DCRT plan (P=0.007 and P=0.008, respectively). The PADDICKCI mean values for PTV1 and PTV2 revealed that 3DCRT plans were significantly worse than IMRT plans (P=0.011 and P=0.009, respectively). For the PTV1, according to the CI assessment, the 9IMRT plan was found to be the best, whereas the TCP assessment found the result in favor of the 7IMRT plan. The best plan for bladder and rectum was found 7IMRT. Although the small bowel volume of 195 cc was the best in 3DCRT, the results in the NTCP and COSI evaluation were in favor of 5IMRT. In addition, the lowest volume receiving half of the dose prescribed for normal tissue was found for 7IMRT in both DVH and COSI evaluation. (5.7% and 0.62, respectively). CONCLUSIONS: In the study, the best technique for RTOGCIPTV1 was found to be 3DCRT, which leads to error in the evaluation. This shows that this index is incompatible with reality in multiple PTV definitions. Another index, PADDICKCI, takes into account the PTV and the organs at risk vicinity of the target. However, this index requires an additional equation in the evaluation of SIB plans. Therefore, we consider the use of TCP and NTCP radiobiological evaluation parameters as importan
Authors and Affiliations
Aysun İNAL, Evrim DUMAN
Keywords
Related Articles
- EP ID EP697227
- DOI https://doi.org/10.18229/kocatepetip.658264
- Views 104
- Downloads 0
FACTORS AFFECTING HOSPITAL MORTALITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE HOSPITALIZED FOR HYPERKALEMIA
OBJECTIVE: Hyperkalemia is an electrolyte imbalance that can lead to fatal results if not corrected. Patients with chronic kidney disease are prone to be hyperkalemic. Knowing the factors associated with hospital mortali...
THE AWARENESS OF MEDICAL STUDENTS OF PULMONOLOGY, THE FACTORS AFFECTING SPECIALITY PREFERENCES, AND THE EFFECT OF COVID-19 ON SPECIALITY PREFERENCE
OBJECTIVE: The aim of this study was to evaluate the, knowledge level of medical faculty students about the branch of chest diseases, the factors affecting their speciality preferences, and the effect of the COVID-19 pan...
EVALUATION OF ANATOMY COURSE FROM THE STUDENT'S PERSPECTIVES WITHIN THE FRAMEWORK OF INNOVATIVE APPROACHES IN MODERN EDUCATION
OBJECTIVE: Despite the changes in the curriculum of medical faculties in the last 30 years, anatomy education has maintained its importance as a basic discipline. The aim of this study is to evaluate the current situatio...
GENERAL CHARACTERISTICS OF THE GERIATRIC PATIENT POPULATION IN THE EMERGENCY DEPARTMENT
OBJECTIVE: In this study, it was aimed to evaluate the general characteristics of patients aged 65 and over who applied to the emergency department of a state hospital. MATERIAL AND METHODS: In this study, records of pa...
INVESTIGATION OF PARAMETERS AFFECTING SELF-MANAGEMENT POWER IN KIDNEY TRANSPLANT RECIPIENTS
OBJECTIVE: Kidney transplantation is one of the types of renal replacement therapy that can be performed in patients with end-stage renal disease. The power to perform activities that require the patient to maintain his...