The expression assessment of the estrogen, progesterone and HER2 receptors in selected malignant tumors of the salivary glands
Journal Title: Otolaryngologia Polska - Year 2013, Vol 67, Issue 5
Abstract
Introduction: The incidence of the malignant tumors of the salivary glands is relatelively low. However, rapid locoregional progression, distant metastases occurrence and high local recurrence rate occurring despite radical surgical treatment, significantly affect the outcome. Malignant tumors of the salivary glands are characterized by low radiosensitivity and poor response to systemic therapy. Therefore there is a need for new targeted therapies which may improve the prognosis. In some aspects, malignant tumors of the salivary glands are similar to breast cancers. Efficacy of hormonal replacement therapy and the treatment with the monoclonal antibody (trastuzumab) in the treatment of breast cancer is well known and confirmed. Criterion determining the qualification for treatment is the presence of hormone receptors and HER2 receptors in the tumor. Aim: The aim of this study was to evaluate the expression of estrogen receptor, progesterone receptor and HER2 in selected salivary gland malignancies. Materials and methods: Study group consisted of 51 patients with the salivary glands cancer. In the study group there were 42 tumors in the parotid gland, 7 tumors of the submandibular gland, 1 in the mucosa of the cheek and 1 tumor in the tongue. Histologically material comprised of muco-epidermoid carcinoma (10), adenoid-cystic carcinoma (8), salivary duct (7), adenocarcinoma (6), squamous cell carcinoma (6), mioepithelial carcinoma (5) and other (9). In all cases immunohistochemical analysis of the estrogen receptor, progesterone receptor and HER2 receptor was performed. Results: The expression of the estrogen receptor was found in 18% of tumors (9 patients). The expression of the progesterone receptor was found in 20% (10 patients). HER2 expression was found in 10% of tumors and was related to only one histological type of tumor – salivary duct carcinoma. Conclusion: HER2 expression in malignant tumors of the salivary glands, especially in salivary duct carcinoma may be of use in future implementation of new targeted therapies based on monoclonal antibodies.
Authors and Affiliations
Wojciech Golusiński, Anna Wegner, Paweł Trzeciak, Marcin Sówka, Andrzej Kopczyński, Małgorzata Bromboszcz
Keywords
Related Articles
- EP ID EP52212
- DOI -
- Views 93
- Downloads 0
Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness
Introduction. Acoustic neuroma usually presents as an unilateral tumor, seldom – bilateral and rarely in coexistence with other central nervous system neoplasms. The following paper reports such a case of a 21-year-old m...
Znaczenie postępowania pooperacyjnego w operacjach czynnościowych nosa i zatok przynosowych
Introduction. In this work we wish to emphasize the importance of postoperative care of patients who underwent FESS in ENT Department Medical University in Poznań. We feel that too little attention is still being paid to...
Zmiany impedancji elektrod u użytkowników implantów ślimakowych
SUMMARY Impedance measurements are routinely performed during the cochlear implan-tation. These measurements make possible to check, whether all electrodes work correctly and are useful in the monitoring of implant's fun...
Rzadki przypadek śmierci wskutek uduszenia się w następstwie zamknięcia światła górnych dróg oddechowych przez torbiel krtani
SUMMARY The report presents a rare case of suffocation due to upper airways obstruc-tion by a large mucolaryngocoele. The mechanism of death by suffocation was confirmed by histopathological examination of the Iungs whic...
Sprawozdanie z 45 Kongresu.
-<br/><br/>