The Glutathione S-Transferase Activities in the Evaluation Acute Viral Hepatitis B and Chronic Alcoholic Liver Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 23, Issue 5
Abstract
Glutathione S-Transferase is an important hepatic detoxifying enzyme. Half-life of GST alpha in plasma is about1hr; its concentration follows the changes in the hepatocellular damage more rapidly than aspartate amino transferase (AST) or alanine amino transferase (ALT). Aim and Objectives: To validate chronic alcoholic liver disease and acute viral hepatitis B could produce any significant changes in serum glutathione S-transferase activities. Materials and Methods: A total of 120 samples were used in the present research. 20 hepatitis B patient 40 chronic alcoholic hepatitis patients and 60 age and sex matched control subjects. Serum GST activity and standard LFT (Liver Function Test) parameters done. Results: GST activity showed a significantly increase (p value< 0.001) in chronic alcoholic liver disease patients (22.293±4.159 IU/L vs 20.127±4.789 IU/L) and in acute viral hepatitis (23.685±6.751 IU/L vs 20.127±4.789 IU/L). In multiple logistic regression analysis when GST measurement was added to a LFT, the diagnostic significance increased from R2=0.792 to 0.884 in acute viral hepatitis B and from R2= 0.843 to 0.849 in chronic alcoholic cirrhosis. Standard LFT parameters are significantly different in both groups. Area under ROC (Receiver Operative Characteristic Curve) is 0.952 for model having albumin+ ALT which is increased to 0.992 after addition of GST in previous model in acute viral Hepatitis B. While in alcoholic Hepatitis Area under ROC is 0.966 for model having albumin+ ALT which is increased to 0.974 after addition of GST in previous model. Conclusion: GST activity may provide additional LFT measurement to the current battery of tests to differentiate acute hepatitis B and alcoholic liver disease from normal population and may improve the evaluation of Hepatitis B virus and alcoholic cirrhosis when added to routine LFT parameters.
Authors and Affiliations
S. D. Sawant, M. R. Mogarekar
Keywords
Related Articles
- EP ID EP312357
- DOI 10.9734/JAMMR/2017/35540
- Views 87
- Downloads 0
Assessment of Left Ventricular Diastolic Function Morbidity in Chronic Obstructive Lung Disease in Population of West Bengal
Introduction: Right ventricular dysfunction is a well known complication or association of Chronic obstructive pulmonary disease (COPD). Only recently the association of Left ventricular dysfunction with COPD has gained...
Medical Students’ Knowledge and Attitudes towards Self-Medication in Al-Iraqia University, Baghdad, Iraq
Introduction: Self-medication is a serious issue worldwide and its irrational use becomes a major cause of global concern. Aims: The present study aimed to determine the knowledge of and attitude of students towards sel...
Evaluation of the Female Sexual Dysfunction in a Sample of Iranian Infertile Women
Introduction: Female sexual dysfunction (FSD) is recognized as a widespread health problem. Infertility may result in increased sexual dysfunction. The aim of this study was to evaluate the prevalence of FSD and some dem...
Histological Study on the Anterior Pituitary Gland of Monosodium Glutamate-Administered Adult Male Wistar Rats
The routine use of Monosodium glutamate (MSG) as a food additive found in commercial food products has being generating controversy regarding its health effects. This study investigated the effects of MSG administration...
Prevalence of Musculoskeletal Injuries among Adolescent Recreational Netballers in Kwa-Zulu Natal, South Africa
Background: Netball injuries remain an area of concern for professional and recreational South African players. This study profiled the prevalence of acute musculoskeletal injuries among female adolescent non-elite recre...