The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients
Journal Title: Progress in Health Sciences - Year 2016, Vol 6, Issue 1
Abstract
Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer
Authors and Affiliations
K. Jakubowska, A. Pryczynicz, V. Dymicka-Piekarska, D. Cepowicz, Ł. Lewczuk, M. Ozimkiewicz, P. Kiszło
Keywords
Related Articles
- EP ID EP186936
- DOI 10.5604/01.3001.0009.5108
- Views 86
- Downloads 0
K-RAS mutations in colorectal cancer in patients from Podlaskie region
Introduction: In Poland, colorectal cancer is the second leading cause of death. The incidence of colorectal cancer increases with age and early onset indicates and increased likelihood for genetic predisposition for thi...
Neuromobilization and kinesiotaping as modern methods used in physiotherapy
Kinesiotaping and neuromobilization techniques are classified as physiotherapy methods in other words, these are the methods used to treat a patient with the use of movement. Both kinesiotaping and neuromobilization can...
The expression of apoptosis-related proteins in patients with ulcerative colitis
Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and...
Bayesian Network Modeling in Discovering Risk Factors of Dental Caries in Three-Year-Old Children
<br/><b>Purpose</b> - The aim of this study was to use probabilistic graphical models to determine dental caries risk factors in three-year-old children. The analysis was conducted on the basis of the questionnaire data...
Testing knowledge of eye donation: a survey of intensive care nurses
Introduction: Corneal transplantation is a sight restoring procedure that enhances the recipient’s quality of life. Most deceased patients in Intensive Care Units (ICU) are potential eye donors, but the number of referra...