The Haemodynamic Effects of Thiopentone/Propofol and Combined use of Low Dose Thiopentone and Propofol on Induction and Intubation - A Three Modality Comparative Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 7
Abstract
Introduction: Induction, Laryngoscopy and Intubation are the points at which haemodynamic changes occur during conduct of anaesthesia, with such changes leading to deleterious systemic effects in vulnerable patients. This study was conducted to compare the haemodynamic effects on induction, and intubation with endotracheal tube with conventional doses of thiopentone and propofol separately and with combined use of low dose of thiopentone and propofol. Material and methods: The study was conducted on 90 patients of ASA Grade - I and II, and of Age between 20- 50 years posted for Elective Surgery. The 90 patients were randomly assigned to three groups of 30 each. Thiopentone (5mg/kg), Propofol (2.5mg/kg) or A combination of low dose of both Thiopentone (2.5mg/kg) and Propofol (1.5mg/kg) was used as induction agent in Groups – I, II and III respectively. Heart Rate and Blood Pressure were measured non-invasively at various (Five) times - At Pre-induction, one minute after the last injection of induction drug i.e., before the performance of Laryngoscopy and Endotracheal tube placement, and at First, Third and Fifth minute of Endotracheal tube placement. Results: The adjusted mean values of Systolic blood pressure, Diastolic blood pressure and Heart rate were assessed by Paired comparisons, by considering the variable of time. All changes were significantly different between Groups I and II. Moreover, changes in systolic and diastolic blood pressures were significantly different between Groups I and III. They were not significant for Heart rate. No significant difference was noted between Groups II and III; showing that in these groups the haemodynamic changes were small during drug injection, Laryngoscopy and Intubation as well as until five minutes after Endotracheal placement. Conclusion: The Combined use of low dose of Thiopentone and Propofol (Group-III) for anaesthetic induction and Intubation caused less Haemodynamic changes than the higher individual dose of either alone.This modality of Anaesthesia induction may have clinical importance for the Elderly patients as well as those with Hypertension and Heart diseases and those belonging to ASA Grade – III and IV.
Authors and Affiliations
Anne Kiran Kumar, Kaluvala Prasad Rao, Metta Rajasekhar, Anyapu Praveena, Jillella Sindhuja, Gopinath Ramchandran
Keywords
Related Articles
- EP ID EP431442
- DOI -
- Views 149
- Downloads 0
A Comparative Study of Intrathecal Dexmedetomidine and Clonidine as an Adjuvant to Hyperbaric Bupivacaine in Surgeries for Fracture Femur and Tibia
Introduction: Intrathecal α2-agonists are used as adjuvant drugs to local anesthetics. Study aimed to compare the effect of intrathecal dexmedetomidine and clonidine as an adjuvant to hyperbaric bupivacaine in patients u...
Concomitant Boost on Saturdays in Radiotherapy for Locally Advanced Oral Cavity and Oropharyngeal Cancers
Introduction: Head and neck cancer is a major health problem in Asia, especially in the Indian subcontinent. Study aimed to assess the response of concomitant boost radiotherapy against the concurrent chemoradiotherapy i...
A Comparative Study of Platelet Indices in Acute Coronary Syndrome
Introduction: Platelet indices are simple and reliable indicators of emerging biomarkers of cardiovascular events and might potentially help in stratifying cardiovascular risk. Studying this correlation may help us in ti...
Rate of Preeclampsia Influenced by Severity of Gestational Diabetes
Gestational Diabetes Mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. GDM has well known adverse effects on pregnancy and its outcome, especially on the fet...
Comparison of Glottis View and Hemodynamic Response by using Macintosh and MacCoy Laryngoscopes for Endotracheal Intubation in General Anaesthesia for Elective Surgery
Introduction: The aim of laryngoscopy is to obtain good visualization of the vocal cords to facilitate smooth endotracheal intubation. To reduce hemodynamic response to Intubation, laryngoscope blades of different shapes...