THE HEALTH BENEFITS OF NATURAL SKIN UVA PHOTOPROTECTIVE COMPOUNDS FOUND IN BOTANICAL SOURCES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 3
Abstract
In recent years, botanicals have gained importance due to their dermal photoprotective effect against the harmful UV radiation. This radiation generates reactive oxygen species which attack proteins, lipids, and nucleic acids among others. This leads to the cellular oxidation, which is reflected as tanning, skin inflammation, erythema, immunosuppression, photoaging and skin cancer. The photoprotective activity of synthetic sunscreens is unsatisfactory due the proved incomplete spectral protection, toxicity, and allergenicity. The phytotherapy treatment with antioxidant compounds with potential UV absorbing capacity could offer a more effective photoprotection since they may impede, reverse or delay the process of formation of DNA adducts. The wide diversity of botanicals with photoprotective activity is attributed to several types of substances with phenolic chromophores. These compounds can be classified as flavonoids, phytoestrogens, carotenoids, xhantophylls, coumarins, proanthocyanidins, anthocyanins, catechins, phenolic acids, triterpenes, alkaloids, etc. The bioactivity of these compounds is not limited to the photoprotective action, but antioxidant, anti-inflammatory, antimutagenic and immunomodulatory properties. The regular intake of these botanicals not only prevents but also delays the deleterious effects of sun radiation onto the skin. Therefore, these botanicals have gained considerable attention and are now included in most vitamin and cosmetic products. This review gives an overview of photoprotective botanicals mainly focused on UVA chromophores that are able to inhibit or reverse the damaging effects of sun radiation. The search criterion was made essentially on UVA photoprotective botanicals and related works published in the last ten years. The literature search included mainly the Google scholar, Science direct, and ISI web of knowledge databases.Keywords: Ultraviolet radiation, Photoprotective botanicals, Antioxidants, Phytotherapy.
Authors and Affiliations
John Rojas, Cesar LondoÑo, Yhors Ciro
Keywords
Related Articles
- EP ID EP577761
- DOI -
- Views 45
- Downloads 0
LIGAND BASED PHARMACOPHORE MODELING, VIRTUAL SCREENING AND MOLECULAR DOCKING STUDIES TO DESIGN NOVEL PANCREATIC LIPASE INHIBITORS
Objective: To understand the essential structural features required for pancreatic lipase (PL) inhibitory activity and to design novel chemical entities, ligand-based pharmacophore modeling, virtual screening and docking...
CHARACTERIZATION OF HYDRODISTILLATED POMELO PEEL OIL AND THE ENHANCEMENT OF BIOLOGICAL ACTIVITIES USING MICROEMULSION FORMULATIONS
Objective: The present study aims to investigate the compositions and biological activities of essential oil extracted from pomelo peel and develop into microemulsions.Methods: Four subspecies of pomelo including Kao-Nam...
SIMULTANEOUS DETERMINATION OF CARVEDILOL AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL DOSAGE FORM BY FIRST ORDER DERIVATIVE UV SPECTROPHOTOMETRY
Objective: To develop an accurate, precise and linear UV spectrophotometry method for simultaneous determination of Carvedilol and Hydrochlorothiazide in Co-Dilatrol® tablet and validate as per ICH guidelines.Methods: D...
STRESS DEGRADATION STUDIES AND DEVELOPMENT OF A VALIDATED RP-HPLC METHOD FOR DETERMINATION OF TIAGABINE IN PRESENCE OF ITS DEGRADATION PRODUCTS
Objective: To develop a simple and rapid isocratic reversed-phase high-performance liquid chromatography (RP-HPLC) method and validate as per ICH and USP guidelines for analysis of tiagabine in the presence of its degrad...
POTENTIAL DRUG-DRUG INTERACTIONS IN HEART FAILURE PATIENTS
Objective: The aim of the present study was to assess the prevalence, risk rating and the severity of hazardous pDDIs (potential drug-drug interactions) in the prescribed pharmacotherapy in the hospital discharged heart...