The impact of nephrectomy on bone health
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2017, Vol 71, Issue
Abstract
Normal kidneys function plays a crucial role in maintaining bone health. This fact is highlighted by the mineral-bone disorder resulting from chronic kidney disease (CKD). CKD impairs the skeletal structure, which in turn leads to a higher prevalence of bone fractures. Because nephrectomy results in a reduced number of nephrons, the question arises if surgically induced nephron loss causes alterations in bone health similar to those observed in CKD. A large number of studies draw attention to the fact that nephrectomy leads to mineral disturbances. Recent studies are consistent that nephrectomy leads to a decline in phosphate and calcitriol levels and an increase in parathyroid hormone levels. There is no consensus regarding the impact of surgically induced nephron loss on fibroblast growth factor 23 (FGF-23) levels. Whether the observed alterations translate into increased fractures rate is still unclear. Current data is sparse and further studies are required to evaluate the possible adverse impact of nephrectomy on bone health. This is a review of the literature exploring the impact of nephrectomy on mineral disturbances and bone health.
Authors and Affiliations
Katarzyna Kakareko, Tomasz Hryszko, Beata Naumnik
Retinol-binding protein 4 (RBP4) as the causative factor and marker of vascular injury related to insulin resistance
One of adipokines involved in the development of insulin resistance is retinol-binding protein 4(RBP4). The physiological role of RBP4 is transport of retinol from the liver to peripheral tissues. One of the first events...
Effect of preservation solutions UW and EC on the expression of matrix metalloproteinase II and tissue inhibitor of metalloproteinase II genes in rat kidney
Matrix metalloproteinases and tissue inhibitor of metalloproteinases play an important role in the regulation of mesangial cell proliferation and may be involved in ischemia-reperfusion injuries. Preservation solutions a...
Immunomodulacyjne działanie witaminy D
Układ endokrynny witaminy D odgrywa istotną rolę w regulacji homeostazy wapniowej oraz w metabolizmie kostnym. W badaniach ostatnich dwóch dekad udowodniono również rolę witaminy D w regulowaniu funkcji układu immunologi...
The role of metallothionein in oncogenesis and cancer treatment
Metallothionein is cysteine-rich low molecular mass protein. The involvement of MT in many physiological and pathophysiological processes such as apoptosis, proliferation, angiogenesis, and the detoxification of heavy me...
Siarczan dehydroepiandrosteronu, osteoprotegeryna i jej rozpuszczalny ligand sRANKL a metabolizm kostny u dziewcząt z jadłowstrętem psychicznym
Wstęp: Nieliczne i niejednoznaczne dane o związku między dehydroepiandrosteronem (DHEA) i/lub jego siarczanem – DHEAS a stanem kośćca u chorych na jadłowstręt psychiczny (anorexia nervosa – AN) skłoniły nas do podjęcia b...