The impact of nephrectomy on bone health
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2017, Vol 71, Issue
Abstract
Normal kidneys function plays a crucial role in maintaining bone health. This fact is highlighted by the mineral-bone disorder resulting from chronic kidney disease (CKD). CKD impairs the skeletal structure, which in turn leads to a higher prevalence of bone fractures. Because nephrectomy results in a reduced number of nephrons, the question arises if surgically induced nephron loss causes alterations in bone health similar to those observed in CKD. A large number of studies draw attention to the fact that nephrectomy leads to mineral disturbances. Recent studies are consistent that nephrectomy leads to a decline in phosphate and calcitriol levels and an increase in parathyroid hormone levels. There is no consensus regarding the impact of surgically induced nephron loss on fibroblast growth factor 23 (FGF-23) levels. Whether the observed alterations translate into increased fractures rate is still unclear. Current data is sparse and further studies are required to evaluate the possible adverse impact of nephrectomy on bone health. This is a review of the literature exploring the impact of nephrectomy on mineral disturbances and bone health.
Authors and Affiliations
Katarzyna Kakareko, Tomasz Hryszko, Beata Naumnik
Bladder urotoxicity pathophysiology induced by the oxazaphosphorine alkylating agents and its chemoprevention
The use of oxazaphosphorines (cyclophosphamide, ifosfamide) in the treatment of numerous neoplastic disorders is associated with their essential adverse effect in the form of hemorrhagic cystitis, which considerably limi...
Nowy sposób indukcji hiperemii wieńcowej
Koronarografia i pomiar cząstkowej rezerwy przepływu wieńcowego (FFR) służą do anatomicznej i czynnościowej oceny zwężeń w tętnicach wieńcowych. Prawidłowy pomiar FFR krytycznie zależy od uzyskania maksymalnego przekrwie...
Is there an effect of folic acid supplementation on the coagulation factors and C-reactive protein concentrations in subjects with atherosclerosis risk factors?
Introduction: Folic acid (FA) may delay the formation of atherosclerotic lesions. Increased plasma levels of von Willebrand factor (VWF) are observed in cardiovascular disease, which leads to higher risk of thrombosis. F...
Morfogeneza, budowa i właściwości naczyń limfatycznych
W pracy przedstawiono współczesne wyniki badań dotyczące budowy systemu naczyń chłonnych, sposobów powstawania naczyń podczas rozwoju osobniczego oraz w warunkach patologicznych, takich jak nowotworzenie, gojenie się ran...
Białko C-reaktywne (CRP) jako czynnik diagnostyczny i prognostyczny w nieswoistych chorobach zapalnych jelit