The Impact of Oxidative Stress on Testicular Function and the Role of Antioxidants in Improving it: A Review
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Oxidative stress is an important factor for development of male infertility because of very high rate of cell division and mitochondrial oxygen consumption in testicular tissue as well as comparably higher levels of unsaturated fatty acids in this tissue than in other tissues. Moreover, the level of oxygen pressure is low due to the weakness of testicular artery; therefore, there is a severe cell competition for oxygen. Therefore, the testicular tissue and male reproductive system are particularly susceptible to oxidative stress. On the other hand, exposure to X-ray, toxins and chemicals found in the environment as well as specific physical conditions such as varicocele can exacerbate the oxidative stress and induce apoptosis of germ cells and subsequently spermatogenesis. However, under normal conditions, the body's capacity to produce antioxidants for inhibiting adverse effects of oxidative stress is affected by metabolic process and genetic structure. Besides that, environmental factors such as diet, pollutants, and chemicals can affect this capacity. Thus, the body's antioxidant system alone is not able to neutralize all free radicals and prevent harmful complications of oxidative stress. Therefore, use of antioxidants and development of antioxidant therapy can break down the oxidative chain reaction and play a very significant role in increasing the body's capacity to fight free radical-induced oxidative stress, and therefore improve the process of spermatogenesis
Authors and Affiliations
Nematollah Asadi, MAHMOUD BAHMANI, Arash Kheradmand, Mahmoud Rafieian-Kopaei
Keywords
Related Articles
- EP ID EP342258
- DOI 10.7860/JCDR/2017/23927.9886
- Views 72
- Downloads 0
Variation in Morphometry of Vastus Medialis Muscle
Introduction: The Vastus Medialis (VM) muscle divides into two parts, proximal Vastus Medialis Longus (VML) and distal Vastus Medialis Obliquus (VMO). The VMO originates from the tendon of adductor magnus and insert into...
Pre-hypertension and Hypertension in School Children Aged 8 to 17 Years in Southern India: A Community Based Study
ABSTRACT Introduction: Pre Hypertension (pre HT) and Hypertension (HT) in childhood have strong association with cardiovascular disease in adult life. There is scarcity of this data in Indian scenario. Aim: To determine...
A Simple Methodology to Better Appreciate Structures in Mandibular Angle Fractures Using 3-Dimensional Reconstruction Software
Abstract Introduction: In Singapore, fractures of the mandible are common and of which, 32% occur at its angle. Current Two-Dimensional (2D) imaging methods are lacking in accuracy, leading to increased surgical morbidit...
Soft Tissue Foreign Body: Utility of High Resolution Ultrasonography
Introduction: Minor percentage of wooden foreign bodies is radio-opaque. High Resolution Ultrasonography (HRUSG) though existing is sparsely used as a primary imaging modality for diagnosis and localization of retained f...
Gastroenteritis In Pregnancy: Relevance and Remedy
Letter to Editor