The impact of Silymarin on improvement of platelet abnormalities in patients with severe preeclampsia
Journal Title: Electronic Physician - Year 2016, Vol 8, Issue 5
Abstract
BACKGROUND: Preeclampsia is a pregnancy-specific disorder that is associated with an increase in blood pressure and proteinuria; in severe cases, it can cause platelet abnormalities. Silymarin is the extract of Silybum marianum, which is recognized as a safe antioxidant drug. OBJECTIVE: To determine the impact of Silymarin on the improvement of severe preeclampsia in 60 patients with severe preeclampsia. METHODS: In this double-blind clinical trial study, This study included 60 patients whose pregnancies were terminated because of severe preeclampsia and who were referred to Hajar Hospital in Shahrekord, Iran, from April 2014 to September 2015. The patients were divided randomly into two groups, i.e., a group of 30 patients and a control group of 30 patients. In addition to the current treatments for preeclampsia, The members of the study group were administered 70 mg of Silymarin at three hours and 24 hours after the termination of their pregnancies. The control group received a placebo at the same times. Platelet count tests were compared at the baseline and at 12, 36, and 60 hours post-measurements in the two groups by SPSS software, version 22, by the ANOVA test, and by the independent-samples t-test. RESULTS: At the baseline, the two groups were not significantly different in terms of various criteria, such as age, BMI, and platelet counts. There were no significant differences between the two groups regarding the number of platelets at 12, 36, and 60 h after their pregnancies were ended (p > 0.01). CONCLUSIONS: The results of this study indicated that, although oxidative factors are involved in the incidence of complications of preeclampsia, e.g., thrombocytopenia, merely using an oxidative agent does not alleviate this effect. This indicated that other factors likely are involved in the pathogenesis of this disease. Additional studies are needed to prove the beneficial effects of this drug in the treatment of preeclampsia. CLINICAL TRIAL REGISTRATION: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT201509042388/N1. FUNDING: Shahrekord University of Medical Sciences supported this research (project no. 2006)
Authors and Affiliations
Baghbahadorani FK, Miraj S
Keywords
Related Articles
- EP ID EP324386
- DOI 10.19082/2436
- Views 90
- Downloads 0
Exploring perceptions of health caregivers on the causes of caregivers’ occupational burnout in institutes of children with cerebral palsy: A qualitative study
BACKGROUND: Providing care for children with cerebral palsy (CP) is hard, energy-consuming, and long-term. Consequently, occupational burnout is highly probable for caregivers. OBJECTIVE: This study aimed to explore the...
Brain Natriuretic Peptide in Liver Cirrhosis and Fatty Liver: Correlation with Cardiac Performance.
The aims of the present study were to assess the serum BNP level in patients with post hepatitis C liver cirrhosis and patients with fatty liver and to determine the correlation between BNP and the severity of liver dise...
Diagnostic Value of the Risk of Malignancy Index (RMI) for Detection of Pelvic Malignancies Compared with Pathology.
Pelvic masses are among most the common causes of patient admission into gynecology clinics and one of the most common reasons for referral to gynecologic oncology departments due to the risk of uterine or ovarian malign...
Conference Report: International Conference on Health Sciences and Medical Technologies, Tlemcen, Algeria 27–29 September 2016 ICHSMT’16
The International Conference on Health Sciences and Medical Technologies (ICHSMT'16) was held in Tlemcen, Algeria from 27-29 September 2016. The conference was organized by the University Of Tlemcen, in partnership with...
Radiographic assessment of maxillary sinus lateral wall thickness in edentulous posterior maxilla
BACKGROUND AND AIM: Given the importance of evaluating the maxillary sinus lateral wall thickness (LWT) to avoid complications during surgery, the aim of this study was to examine LWT as well as the effect of residual ri...