The improvement of treatment efficacy of gastropathy associated with the use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-negative patients with osteoarthritis
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2014, Vol 27, Issue 4
Abstract
Among the more common side effects of osteoarthritis treatment are NSAID-gastropathy and NSAID-enteropathy. NSAIDs can cause direct injury to colon tissue and also impair synthesis of prostaglandins, reduce mucosal integrity, increase permeability and promote an influx of bacteria and toxins. Alterations in gastrointestinal permeability are considered as an initial step in the development of lesions of the gastric mucosa such as erosions and ulcers. The mechanisms underlying the ability of NSAIDs to cause ulceration in the stomach and proximal duodenum are well understood and this injury can be largely be prevented through suppression of gastric acid secretion. However, our work showed that 28-day administration of the anti-secretory preparation pantoprazole (20 mg 2 times per day) resulted in a statistically significant increase of dysbiosis. Monitoring of patients with osteoarthritis who used NSAIDs for more than three months showed that, in comparison to the situation before the beginning of treatment, changes in colonic microbiota were present. Multiprobiotic “Symbiter® acidophilic concentrated” introduced simultaneously with pantoprazole during 20 days prevented formation of dysbiotic changes and led to the quicker healing of gastric mucous healing, in comparison with patients who used only pantoprazole alone. Moreover, it brought about total healing of the gastric mucosa within 4 weeks from the beginning of treatment.
Authors and Affiliations
Antonina Antonenko, Tetyana Beregova
Keywords
Related Articles
- EP ID EP116689
- DOI 10.1515/cipms-2015-0023
- Views 86
- Downloads 0
Simultaneous determination of amlodipine and telmisartan from pharmaceutical products by way of capillary electrophoresis
A rapid, simple and sensitive capillary zone electrophoresis method was developed for the simultaneous determination of amlodipine besylate and telmisartan, in fixed-dose combinations, through the utilization of a UV pho...
Littoral cell angioma mimicking metastatic tumors
Littoral cell angioma is a rare primary, vascular tumor thought to originate from the endothelial cells lining the sinuses of the splenic red pulp (the “littoral cells”). It is a benign, usually asymptomatic lesion diagn...
Factors determining healthy work conditions in the beauticians' workplace
The beauty studio is a place of work where a beautician and her customers spend several hours, hence, it has to meet certain basic hygiene requirements so as to provide employees and customers conditions that keep them s...
Therapeutic management of macrodontic tooth
Macrodontic tooth (in Latin: macrodens) is an anomaly of the structure of a tooth; it usually refers to the medial upper incisors, and is usually the cause of malocclusion in the anterior jaw. The aim of this study was t...
Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis
This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swis...